Home   Chapter Home   Jobs   Conferences   Fellowships   Books



Advertisement

Liver and intrahepatic bile ducts-nontumor

Developmental anomalies/cysts

von Meyenburg complex


Reviewers: Komal Arora, M.D. (see Reviewers page)
Revised: 23 April 2012, last major update April 2012
Copyright: (c) 2004-2012, PathologyOutlines.com, Inc.

General
=========================================================================

● Also called bile duct hamartoma or microhamartoma
● Incidental finding in 6% of adults and 1% of children at autopsy; found in 1% of all liver needle biopsies
● No clinical significance, although may resemble liver metastases to surgeons
● A type of ductal plate malformation, due to incomplete involution of embryonic bile duct remnants
● Associated with other ductal plate malformations such as congenital hepatic fibrosis and Caroliís disease; also autosomal dominant polycystic hepatorenal disease
● Rarely associated with neoplastic transformation to hyperplasia, adenoma, cholangiocarcinoma (Am J Surg Pathol 2000;24:1131, Arch Pathol Lab Med 2000;124:1704)

Gross description
=========================================================================

● Single or multiple (20% have 4+ nodules) well circumscribed nodules, subcapsular, gray-white, occasionally green; often less than 5 mm

Micro images
=========================================================================



Bile duct hamartoma

Micro description
=========================================================================

● Periportal small clusters of modestly dilated bile ducts, often angulated, in fibrous stroma
● May contain intraluminal bile
● Epithelial cells are bland
● Usually no/minimal inflammatory infiltrate, no atypia

Micro images
=========================================================================


       
Periportal cluster of dilated bile ducts


Dilated bile ducts in fibrous stroma (figure 3)

Positive stains
=========================================================================

● Mucin (variable)

End of Liver and intrahepatic bile ducts-nontumor > Developmental anomalies/cysts > von Meyenburg complex


This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).