Liver and intrahepatic bile ducts-nontumor
von Meyenburg complex
Reviewers: Komal Arora, M.D. (see Reviewers page)
Revised: 23 April 2012, last major update April 2012
Copyright: (c) 2004-2012, PathologyOutlines.com, Inc.
● Also called bile duct hamartoma or microhamartoma
● Incidental finding in 6% of adults and 1% of children at autopsy; found in 1% of all liver needle biopsies
● No clinical significance, although may resemble liver metastases to surgeons
● A type of ductal plate malformation, due to incomplete involution of embryonic bile duct remnants
● Associated with other ductal plate malformations such as congenital hepatic fibrosis and Caroliís disease; also autosomal dominant polycystic hepatorenal disease
● Rarely associated with neoplastic transformation to hyperplasia, adenoma, cholangiocarcinoma (Am J Surg Pathol 2000;24:1131, Arch Pathol Lab Med 2000;124:1704)
● Single or multiple (20% have 4+ nodules) well circumscribed nodules, subcapsular, gray-white, occasionally green; often less than 5 mm
Bile duct hamartoma
● Periportal small clusters of modestly dilated bile ducts, often angulated, in fibrous stroma
● May contain intraluminal bile
● Epithelial cells are bland
● Usually no/minimal inflammatory infiltrate, no atypia
Periportal cluster of dilated bile ducts
Dilated bile ducts in fibrous stroma (figure 3)
● Mucin (variable)
End of Liver and intrahepatic bile ducts-nontumor > Developmental anomalies/cysts > von Meyenburg complex
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