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Lymph nodes - not lymphoma
Inflammatory disorders (non-infectious)
Sinus histiocytosis with massive lymphadenopathy

Reviewer: William D. DePond, M.D. (see Reviewers page)
Revised: 28 July 2013, last major update June 2006
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
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Radiology images
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Rosai-Dorfman disease: bone

Case reports
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Treatment
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Gross description
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Gross images
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Rosai-Dorfman disease: skin

Micro description
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Micro images
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Contributed by Dr. Mark R. Wick

Rosai Dorfman disease

S100


AFIP images:

Sinus histiocytosis with massive lymphadenopathy


Sinus histiocytosis with massive lymphadenopathy

Sinus histiocytosis with massive lymphadenopathy


Sinus histiocytosis with massive lymphadenopathy

Touch imprint of lymph node

Rosai-Dorfman disease: extranodal

Rosai-Dorfman disease: eye


Sinus histiocytosis with massive lymphadenopathy S100

Rosai-Dorfman disease: extranodal S100



Other images:

Histiocytes fill a nodal sinus


Extensive replacement of nodal architecture by pale staining cells

Distended sinus contains lymphocytes with ingested lymphocytes

Thyroid nodule



Cytology description
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Positive stains
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Negative stains
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Molecular description
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Differential diagnosis
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End of Lymph nodes - not lymphoma > Inflammatory disorders (non-infectious) > Sinus histiocytosis with massive lymphadenopathy


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