Oral cavity
Other benign tumors / conditions
Squamous papilloma

Author: Nat Pernick, M.D. (see Authors page)

Revised: 23 April 2018, last major update November 2013

Copyright: (c) 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: Squamous papilloma[TIAB] oral

Cite this page: Pernick, N. Squamous papilloma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/oralcavitysquamouspapilloma.html. Accessed July 21st, 2018.
Definition / general
  • Common intraoral benign epithelial neoplasm
  • Mean age 38 years
  • 50% associated with human papillomavirus (HPV 6 and 11); others may represent reactive epithelial hyperplasia
  • Sites: posterior hard palate, soft palate and uvula (34%), dorsum and lateral tongue borders (24%), gingiva (12%), lower lip (12%) and buccal mucosa (6%)
Treatment
  • Excision; 4% recur
Gross description
  • White-pink cauliflower-like surface projections, 75% are less than 1 cm
Microscopic (histologic) description
  • Delicate fibrovascular cores surrounded by benign squamous epithelium
  • Hyperkeratosis in 82%, parakeratosis in 72%
  • Variable hyperplasia of basilar, parabasilar, prickle cell or granular cell layers, individual cell keratinization and abnormal mitotic figures
  • Often no koilocytotic changes; no downward pushing growth into lamina propria
  • Dysplasia: significant cytologic atypia and maturation abnormalities