Oral cavity
Other benign tumors / conditions
Squamous cell papilloma

Topic Completed: 1 November 2013

Minor changes: 21 April 2020

Copyright: 2002-2020, PathologyOutlines.com, Inc.

PubMed Search: Squamous papilloma[TIAB] oral

Nat Pernick, M.D.
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Cite this page: Pernick N Squamous cell papilloma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/oralcavitysquamouspapilloma.html. Accessed May 28th, 2020.
Definition / general
  • Common intraoral benign epithelial neoplasm
  • Mean age 38 years
  • 50% associated with human papillomavirus (HPV 6 and 11); others may represent reactive epithelial hyperplasia
  • Sites: posterior hard palate, soft palate and uvula (34%), dorsum and lateral tongue borders (24%), gingiva (12%), lower lip (12%) and buccal mucosa (6%)
  • Excision; 4% recur
Gross description
  • White-pink cauliflower-like surface projections, 75% are less than 1 cm
Microscopic (histologic) description
  • Delicate fibrovascular cores surrounded by benign squamous epithelium
  • Hyperkeratosis in 82%, parakeratosis in 72%
  • Variable hyperplasia of basilar, parabasilar, prickle cell or granular cell layers, individual cell keratinization and abnormal mitotic figures
  • Often no koilocytotic changes; no downward pushing growth into lamina propria
  • Dysplasia: significant cytologic atypia and maturation abnormalities
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