Ovary tumor
Other tumors not specific to ovary
Fibrosarcoma

Author: Nalini Gupta, M.D. (see Authors page)

Revised: 13 September 2018, last major update June 2016

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: fibrosarcoma [title] ovary
Cite this page: Gupta, N. Fibrosarcoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/ovarytumorfibrosarcoma.html. Accessed November 21st, 2018.
Definition / general
  • Very rare (<100 reported cases) aggressive tumor which arises directly from stromal cells or from preexisting cellular fibroma
  • More common in bone
Epidemiology
  • Median age 49 years, range 20-73 years
Clinical features
Laboratory
  • CA125 and CEA in normal range
Radiology description
Prognostic factors
Case reports
Treatment
  • Surgical resection with or without adjuvant chemotherapy or radiation
Gross description
Gross images

Images hosted on other servers:

Capsular disruption and hemorrhage

Microscopic (histologic) description
  • Spindle cells arranged in sheets and intersecting fascicles creating a diffuse herringbone appearance
  • Mild to moderate nuclear atypia
  • Reticulin stain separates individual neoplastic cells
  • Mitotic activity > 4/10 HPF is most important criteria for diagnosing fibrosarcoma
Microscopic (histologic) images

Images hosted on PathOut server:

Various images



Images hosted on other servers:

Various images

Cytology description
  • Pleomorphic oval to spindle shaped cells with indistinct cell borders and atypical mitotic figures
Cytology images

Images hosted on other servers:

Clusters of pleomorphic spindle cells

Molecular / cytogenetics description
Differential diagnosis