Ovary tumor
Other tumors not specific to ovary

Author: Nalini Gupta, M.D. (see Authors page)

Revised: 29 June 2016, last major update June 2016

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed Search: fibrosarcoma [title] ovary
Cite this page: Fibrosarcoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/ovarytumorfibrosarcoma.html. Accessed October 22nd, 2016.
Definition / General
  • Very rare (<100 reported cases) aggressive tumor which arises directly from stromal cells or from preexisting cellular fibroma
  • More common in bone
  • Median age 49 years, range 20-73 years
Clinical Features
  • CA125 and CEA in normal range
Radiology Description
Prognostic Factors
Case Reports
  • Surgical resection with or without adjuvant chemotherapy or radiation
Gross Description
Gross Images

Images hosted on other servers:

Capsular disruption and hemorrhage

Micro Description
  • Spindle cells arranged in sheets and intersecting fascicles creating a diffuse herringbone appearance
  • Mild to moderate nuclear atypia
  • Reticulin stain separates individual neoplastic cells
  • Mitotic activity > 4/10 HPF is most important criteria for diagnosing fibrosarcoma
Micro Images

Various images

Cytology Description
  • Pleomorphic oval to spindle shaped cells with indistinct cell borders and atypical mitotic figures
Cytology Images

Images hosted on other servers:

Clusters of pleomorphic spindle cells

Molecular / Cytogenetics Description
Differential Diagnosis