Sex cord stromal tumors


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Last staff update: 23 August 2022

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PubMed Search: fibrosarcoma [title] ovary

Nalini Gupta, M.D.
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Cite this page: Gupta N. Fibrosarcoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/ovarytumorfibrosarcoma.html. Accessed June 2nd, 2023.
Definition / general
  • Very rare (< 100 reported cases) aggressive tumor which arises directly from stromal cells or from preexisting cellular fibroma
  • More common in bone
  • Median age 49 years, range 20 - 73 years
Clinical features
  • CA125 and CEA in normal range
Radiology description
Prognostic factors
Case reports
  • Surgical resection with or without adjuvant chemotherapy or radiation
Gross description
Gross images

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Capsular disruption and hemorrhage

Microscopic (histologic) description
  • Spindle cells arranged in sheets and intersecting fascicles creating a diffuse herringbone appearance
  • Mild to moderate nuclear atypia
  • Reticulin stain separates individual neoplastic cells
  • Mitotic activity > 4/10 HPF is most important criteria for diagnosing fibrosarcoma
Microscopic (histologic) images

AFIP images

Moderate cytologic atypia

Cytology description
  • Pleomorphic oval to spindle shaped cells with indistinct cell borders and atypical mitotic figures
Cytology images

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Clusters of pleomorphic spindle cells

Molecular / cytogenetics description
Differential diagnosis
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