Other tumors

Topic Completed: 1 June 2016

Minor changes: 11 March 2020

Copyright: 2003-2020, PathologyOutlines.com, Inc.

PubMed Search: fibrosarcoma [title] ovary

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Cite this page: Gupta N. Fibrosarcoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/ovarytumorfibrosarcoma.html. Accessed August 7th, 2020.
Definition / general
  • Very rare (< 100 reported cases) aggressive tumor which arises directly from stromal cells or from preexisting cellular fibroma
  • More common in bone
  • Median age 49 years, range 20 - 73 years
Clinical features
  • CA125 and CEA in normal range
Radiology description
Prognostic factors
Case reports
  • Surgical resection with or without adjuvant chemotherapy or radiation
Gross description
Gross images

Images hosted on other servers:

Capsular disruption and hemorrhage

Microscopic (histologic) description
  • Spindle cells arranged in sheets and intersecting fascicles creating a diffuse herringbone appearance
  • Mild to moderate nuclear atypia
  • Reticulin stain separates individual neoplastic cells
  • Mitotic activity > 4/10 HPF is most important criteria for diagnosing fibrosarcoma
Microscopic (histologic) images

AFIP images

Various images

Cytology description
  • Pleomorphic oval to spindle shaped cells with indistinct cell borders and atypical mitotic figures
Cytology images

Images hosted on other servers:

Clusters of pleomorphic spindle cells

Molecular / cytogenetics description
Differential diagnosis
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