Pancreas
Exocrine tumors / carcinomas
Undifferentiated carcinoma - osteoclastic giant cell tumor

Author: Deepali Jain, M.D. (see Authors page)

Revised: 22 December 2017, last major update August 2012

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Undifferentiated carcinoma osteoclastic giant cell tumor

Cite this page: Jain, D. Undifferentiated carcinoma - osteoclastic giant cell tumor. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/pancreasosteoclastic.html. Accessed October 24th, 2018.
Definition / general
Case reports
Gross description
  • Large, hemorrhagic
Gross images

Images hosted on other servers:

77 year old woman

Microscopic (histologic) description
  • Contain 5 cellular components: osteoclast-like giant cells, pleomorphic large cells, histiocyte-like mononuclear cells, atypical mononuclear cells (nucleus resembles pleomorphic large cells), ductal carcinoma cells
Microscopic (histologic) images

Images hosted on PathOut server:

Osteoclast-like giant cells and bizarre tumor giant cells are mixed with a few spindle and smaller pleomorphic cells; osteoclast-like cells are relatively uniformly nucleated and each nucleus has little chromatin and one small distinct nucleolus


Rare small focus of adenocarcinoma

Elongated spindle cells vary from those with small cell nuclei and relatively little chromatin to cells containing abundant chromatin; an osteoclast-like giant cell can be seen at upper left


Osteoid formation (lower right) with a few osteoclast-like giant cells, plus many small, pleomorphic, mononucleated cells

Osteoclast giant cells are LCA / CD45+; nonneoplastic macrophages and lymphocytes are also immunoreactive



Images hosted on other servers:

77 year old woman

Cytology images

Images hosted on other servers:

Osteoclastic giant cell tumor of pancreas

Positive stains
  • Osteoclast-like giant cells: CD68+, keratin negative, no KRAS mutation; nonneoplastic
  • Pleomorphic large cells (not always present): CD68-, often have KRAS mutations
  • Histiocyte-like mononuclear cells: CD68+, keratin+, often have KRAS mutations
  • Atypical mononuclear cells: CD68-, often have KRAS mutations
  • Ductal carcinoma cells: CD68-, same KRAS mutations as pleomorphic large cells and mononuclear cells
Electron microscopy images

Images hosted on other servers:

Various images

Molecular / cytogenetics description