Placenta
Non-trophoblastic neoplasms
Chorangiosis

Author: Mandolin Ziadie, M.D. (see Authors page)

Revised: 7 October 2015, last major update November 2011

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: chorangiosis
Cite this page: Chorangiosis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/placentachorangiosis.html. Accessed December 7th, 2016.
Definition / General
  • More than 10 capillaries in at least 10 terminal villi in at least 3 low-power fields of the placenta (normal villi rarely have > 5 capillary lumina)
  • Capillary (NOT stromal) hypercellularity is due to chronic placental hypoperfusion or low-grade tissue hypoxemia
  • May be seen in pre-eclampsia, diabetes mellitus, placentomegaly, high altitudes, drugs and urinary tract infections
  • Associated with neonatal morbidity / mortality (Arch Pathol Lab Med 1984;108:71)
Gross Description
  • Associated with single umbilical artery and other umbilical cord anomalies, retroplacental hematoma (abruptio placentae) and placenta previa
Micro Description
  • More than 10 capillaries in at least 10 terminal villi in at least 3 low-power fields of the placenta
  • Capillaries are not surrounded by a continuous layer of pericytes or associated with stromal fibrosis
  • May be associated with other features of villous dysmaturity, chorangioma, amnion nodosum, chronic villitis and FTV
  • Distinguish from congestion (vessels appear prominent but are normal in number) and tissue ischemia (other features of ischemia include shrunken coalesced villi)
Micro Images

Chorangiosis


Courtesy of Dr. Semir Vranic