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Non-trophoblastic neoplasms


Reviewers: Mandolin Ziadie, M.D. (see Reviewers page)
Revised: 29 November 2011, last major update November 2011
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● More than 10 capillaries in at least 10 terminal villi in at least 3 low-power fields of the placenta (normal villi rarely have > 5 capillary lumina)
● Capillary (NOT stromal) hypercellularity is due to chronic placental hypoperfusion or low-grade tissue hypoxemia
● May be seen in pre-eclampsia, diabetes mellitus, placentomegaly, high altitudes, drugs and urinary tract infections
● Associated with neonatal morbidity / mortality (Arch Pathol Lab Med 1984;108:71)

Gross description

● Associated with single umbilical artery and other umbilical cord anomalies, retroplacental hematoma (abruptio placentae) and placenta previa

Micro description

● More than 10 capillaries in at least 10 terminal villi in at least 3 low-power fields of the placenta
● Capillaries are not surrounded by a continuous layer of pericytes or associated with stromal fibrosis
● May be associated with other features of villous dysmaturity, chorangioma, amnion nodosum, chronic villitis and FTV
● Distinguish from congestion (vessels appear prominent but are normal in number) and tissue ischemia (other features of ischemia include shrunken coalesced villi)

Micro images


End of Placenta > Non-trophoblastic neoplasms > Chorangiosis

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