Placenta
Non-trophoblastic neoplasms
Chorangiosis

Author: Mandolin Ziadie, M.D. (see Authors page)

Revised: 7 October 2015, last major update November 2011

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: chorangiosis
Cite this page: Chorangiosis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/placentachorangiosis.html. Accessed May 22nd, 2017.
Definition / general
  • More than 10 capillaries in at least 10 terminal villi in at least 3 low-power fields of the placenta (normal villi rarely have > 5 capillary lumina)
  • Capillary (NOT stromal) hypercellularity is due to chronic placental hypoperfusion or low-grade tissue hypoxemia
  • May be seen in pre-eclampsia, diabetes mellitus, placentomegaly, high altitudes, drugs and urinary tract infections
  • Associated with neonatal morbidity / mortality (Arch Pathol Lab Med 1984;108:71)
Gross description
  • Associated with single umbilical artery and other umbilical cord anomalies, retroplacental hematoma (abruptio placentae) and placenta previa
Microscopic (histologic) description
  • More than 10 capillaries in at least 10 terminal villi in at least 3 low-power fields of the placenta
  • Capillaries are not surrounded by a continuous layer of pericytes or associated with stromal fibrosis
  • May be associated with other features of villous dysmaturity, chorangioma, amnion nodosum, chronic villitis and FTV
  • Distinguish from congestion (vessels appear prominent but are normal in number) and tissue ischemia (other features of ischemia include shrunken coalesced villi)
Microscopic (histologic) images

Chorangiosis


Courtesy of Dr. Semir Vranic