Anus & perianal area
Carcinoma
Basal cell carcinoma


Topic Completed: 8 March 2021

Minor changes: 8 March 2021

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PubMed Search: Basal cell carcinoma [title] anus

Raul S. Gonzalez, M.D.
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Cite this page: Gonzalez RS. Basal cell carcinoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/anusbasalcell.html. Accessed May 6th, 2021.
Definition / general
Essential features
  • Rare perianal malignancy identical to basal cell carcinoma of skin
Sites
  • Perianal skin (not anus proper)
Pathophysiology
  • Appears to behave similarly to basal cell carcinoma at other locations
Clinical features
Diagnosis
  • Biopsy
Case reports
Treatment
  • Wide local excision with negative margins
Clinical images

Images hosted on other servers:
Perianal basal cell carcinoma

Perianal basal cell carcinoma

Gross description
  • Indurated, ulcerated lesion with irregular borders
Microscopic (histologic) description
  • Resembles basal cell carcinoma at other sites (see Skin nonmelanocytic chapter)
  • Retraction artifact helps distinguish from basaloid squamous cell carcinoma
Microscopic (histologic) images

Contributed by Raul S. Gonzalez, M.D.
Basal cell carcinoma Basal cell carcinoma Basal cell carcinoma

Basal cell carcinoma



Images hosted on other servers:

Cell clusters

Positive stains
Negative stains
Flow cytometry description
Sample pathology report
  • Skin, perianal, resection:
    • Basal cell carcinoma (1.6 cm), completely excised
Differential diagnosis
Board review style question #1

Which of the following is true about perianal basal cell carcinoma?

  1. It accounts for 10% of basal cell carcinomas overall
  2. It can also arise within the anus
  3. It histologically resembles basal cell carcinoma at other sites
  4. It is negative for BerEP4 and BCL2
Board review style answer #1
C. It histologically resembles basal cell carcinoma at other sites

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Reference: Basal cell carcinoma
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