Liver & intrahepatic bile ducts

General

Cirrhosis


Editorial Board Member: Raul S. Gonzalez, M.D.
Deputy Editor-in-Chief: Catherine E. Hagen, M.D.
Anthony W.H. Chan, M.B.Ch.B.

Topic Completed: 7 June 2021

Minor changes: 7 June 2021

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PubMed Search: Liver intrahepatic bile ducts cirrhosis[TI] free full text[sb]

Anthony W.H. Chan, M.B.Ch.B.
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Cite this page: Chan AWH. Cirrhosis. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/livercirrhosis.html. Accessed October 18th, 2021.
Definition / general
  • Diffuse nodulation of liver due to fibrous bands subdividing liver into regenerative nodules
Essential features
  • Diffuse nodulation of liver due to fibrous bands subdividing liver into regenerative nodules
  • Viral hepatitis B / C, alcoholic liver disease, nonalcoholic (metabolic associated) fatty liver disease are most common causes
ICD coding
  • ICD-10:
    • K74.3 - alcoholic cirrhosis
    • K74.5 - biliary cirrhosis
    • K74.6 - unspecified cirrhosis
Epidemiology
Sites
  • Liver
Pathophysiology
  • Combination of processes (J Hepatol 2017;66:778)
    • Fibrosis: excessive production of collagen type I / III by hepatic stellate cells with or without portal fibroblasts through chronic inflammation (tumor necrosis factor [TNF] alpha), transforming growth factor [TGF] beta, IL1), cytokines from Kupffer cells, endothelial cells, bile duct cells, hepatocytes and disruption of extracellular matrix and toxins
    • Regeneration of hepatocytes through proliferation of progenitor cells of the ductular reaction
    • Parenchymal extinction due to vascular disruption
  • Regression (J Hepatol 2015;63:1038)
    • Cirrhosis is potentially reversible after successful treatment of chronic liver disease, e.g. viral hepatitis
    • Cessation of chronic damage allows hepatocyte recovery and modulates the microenvironment
    • Shifting balance from inflammation to resolution results in phenotypic adjustments of immune cells
    • Myofibroblasts are deactivated by senescence, apoptosis and inactivation
    • Matrix degradation also occurs
Etiology
  • Prevalence of causes varies by geographic location
  • Common causes include:
    • Chronic viral hepatitis B (with or without D) and C
    • Fatty liver disease: alcoholic and nonalcoholic (metabolic associated)
    • Metabolic: hereditary hemochromatosis, alpha-1 antitrypsin deficiency, Wilson disease
    • Immune mediated: autoimmune hepatitis, primary biliary cholangitis, primary sclerosing cholangitis
    • Chronic biliary obstruction
    • Drug induced liver injury
    • Cryptogenic (idiopathic) cirrhosis: accounts for 8 - 9% of liver transplants in the U.S.; burnt out nonalcoholic fatty liver disease (NAFLD) / nonalcoholic steatohepatitis (NASH) is a common cause of cryptogenic cirrhosis (Hepatology 2000;32:689)
Clinical features
  • General (nonspecific): malaise, fatigue, anorexia, weight loss
  • Specific (due to impaired liver function):
    • Impaired protein synthesis (leukonychia [white nails], ascites, bruising)
    • Impaired biliary excretion (jaundice, pruritus)
    • Impaired nitrogen metabolism (hepatic encephalopathy)
    • Impaired estrogen metabolism (palmar erythema, spider nevus, testicular atrophy, gynecomastia)
  • Complications:
    • Decompensation: development of jaundice, ascites, variceal hemorrhage or hepatic encephalopathy
    • Portal hypertension: ascites (with or without spontaneous bacterial peritonitis), splenomegaly, esophageal / gastric varices
    • Liver failure: coagulopathy, hepatic encephalopathy, hepatorenal syndrome, hepatopulmonary syndrome, portopulmonary hypertension
    • Hepatocellular carcinoma: cirrhosis is a key risk factor and the annual incidence of HCC among cirrhotic patients is 2 - 8% (Lancet 2014;384:2053, Hepatology 2010;51:1972)
Diagnosis
  • Ultrasound, CT or MRI radiologically
  • Elastography
  • Liver biopsy
Laboratory
  • Clinical subclassification of cirrhosis uses blood with or without clinical parameters
  • Child-Pugh score / grade (J Hepatol 2005;42:S100)
    • 5 parameters: albumin, bilirubin, international normalized ratio (INR) / prothrombin time, ascites and hepatic encephalopathy
    • Each parameter is assigned from 1 - 3
    • Total score ranges from 5 - 15 and is categorized as grade A (5, 6), B (7 - 9) and C (10 - 15)
  • Model for end stage liver disease (MELD) score (J Hepatol 2005;42:S100)
    • 3 parameters: bilirubin, creatinine and INR
    • Used to prioritize need for liver transplantation
  • Albumin bilirubin (ALBI) score / grade (J Clin Oncol 2015;33:550)
    • 2 parameters: albumin, bilirubin
    • Simple, objective and evidence based alternative of Child-Pugh score / grade
Radiology description
  • There are multiple nodular isodense lesions deforming the liver margin on the arterial phase CT
Radiology images

Images hosted on other servers:

Cirrhosis

Case reports
  • 28 year old woman with cirrhosis secondary to autoimmune hepatitis and alpha-1 antitrypsin ZZ phenotype (Cureus 2021;13:e12606)
  • 44 year old man with Wilson disease presenting with muscle stiffness, gait instability and liver cirrhosis (Lancet 2020;396:990)
  • 62 year old man with cirrhosis took daily probiotics and developed Lactobacillus associated spontaneous bacterial peritonitis (Cureus 2020;12:e11896)
Treatment
  • Treating the underlying cause of cirrhosis
  • Treating and preventing complications (ascites, hepatic encephalopathy, variceal hemorrhage, and portal hypertension)
  • Avoid additional liver injury (e.g. alcohol)
  • Patients with MELD ≥ 15 or decompensation should be referred to a transplant center (Hepatology 2014;59:1144)
  • Regular ultrasound surveillance of HCC (Hepatology 2018;68:723)
Gross description
  • Multiple regenerative nodules throughout the entire liver, separated by bridging fibrosis
Gross images

Contributed by Anthony W.H. Chan, M.B.Ch.B.
Cirrhotic liver Cirrhotic liver

Cirrhotic liver



Images hosted on other servers:
Missing Image

Micronodular and
macronodular
cirrhosis

Microscopic (histologic) description
  • Nonbiliary type cirrhosis:
    • Diffuse disruption in architecture of the entire liver (loss of normal central - portal relationship)
    • Bridging fibrous septa
    • Rounded parenchymal nodules of regenerating hepatocytes
  • Biliary type cirrhosis:
    • Diffuse disruption in architecture of the entire liver (loss of normal central - portal relationship)
    • Bridging fibrous septa
    • Irregular, jigsaw puzzle shaped parenchymal nodules of regenerating hepatocytes with peripheral pale halo (peripheral septal edema, loose packed fibrous tissue and chronic cholestasis of periseptal hepatocytes leading to feathery degeneration)
    • Alcoholic type cirrhosis:
      • Micronodular cirrhosis, Mallory bodies, fatty change
      • Perivenular and pericellular fibrosis (highlighted with trichrome stain) with partial / complete obliteration of central vein (identifiable as central vein due to lack of arterioles)
      • More prominent bridging from central zone to central zone and central zone to portal zone than in other causes of cirrhosis
      • Usually few inflammatory cells, unless superimposed viral or alcoholic hepatitis
    • Subclassification: micronodular (< 3 mm) versus macronodular (≥ 3 mm)
      • Typically not very clinically significant
      • Former is more commonly associated with alcoholic liver disease, genetic hemochromatosis and Wilson disease, whereas the latter is more frequently associated with viral hepatitis
      • Micronodular cirrhosis and macronodular cirrhosis may be transformed into each other in either direction, depending on disease activity (Arch Pathol Lab Med 2000;124:1599)
      • Difficult to assess in liver biopsy specimen
    • Subclassification: Laennec fibrosis scoring system (J Hepatol 2011;55:1004)
      • 4A: mild cirrhosis; marked septation with rounded contours or visible nodules; most septa are thin (1 broad septum allowed)
      • 4B: moderate cirrhosis with at least 2 broad septa
      • 4C: severe cirrhosis with at least 1 very broad septum or many minute nodules
      • Excellent interobserver agreement (kappa 0.83)
      • Correlate with severity of portal hypertension and Child-Pugh and MELD scores
Microscopic (histologic) images

Contributed by Anthony W.H. Chan, M.B.Ch.B.
Biliary type cirrhosis

Biliary type cirrhosis

Cirrhosis, hepatitis B virus (HBV)

Cirrhosis, hepatitis B virus (HBV)

Cirrhosis HBV, Sirius red

Cirrhosis HBV, Sirius red

Cirrhosis HBV HBsAg

Cirrhosis HBV, HBsAg

Positive stains
Sample pathology report
  • Liver, biopsy:
    • Steatohepatitis with cirrhosis (see comment)
    • Comment: In clinical history of diabetes mellitus and hypertension without significant alcoholic consumption, the overall features are consistent with metabolic associated fatty liver disease with cirrhosis.
Differential diagnosis
Board review style question #1

What is the factor contributing to the periseptal halo in biliary type cirrhosis, in addition to periseptal edema?

  1. Ballooning degeneration
  2. Bilirubinostasis
  3. Feathery degeneration
  4. Florid duct lesion
  5. Periductal fibrosis
Board review style answer #1
C. Feathery degeneration

Ballooning degeneration is a hallmark pathological change of steatohepatitis, which is not associated with biliary type cirrhosis (answer A). Bilirubinostasis may be present in late biliary type cirrhosis but is not associated with periseptal halo (answer B). Feathery degeneration is one of the features of chronic cholestasis contributing to the periseptal halo in biliary type cirrhosis (answer C). Florid duct lesion is one of the characteristic features of primary biliary cholangitis, which is not associated with periseptal halo (answer D). Periductal fibrosis is one of the characteristic features of primary sclerosing cholangitis, which is not associated with periseptal halo (answer E).

Comment Here

Reference: Cirrhosis
Board review style question #2

A 60 year old man was admitted with massive hematemesis and hypovolemic shock. He failed to respond to resuscitation. Postmortem examination revealed a liver shown as above. What is the most likely cause of his massive gastrointestinal bleeding?

  1. Acute gastritis
  2. Aortoesophageal fistula
  3. Esophageal varices
  4. Hepatocellular carcinoma
  5. Peptic ulcer
Board review style answer #2
C. Esophageal varices

Comment Here

Reference: Cirrhosis
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