Liver & intrahepatic bile ducts

Benign / nonneoplastic

Reactive lymphoid hyperplasia / pseudolymphoma

Topic Completed: 1 February 2012

Minor changes: 17 March 2021

Copyright: 2002-2021,, Inc.

PubMed Search: Reactive lymphoid hyperplasia pseudolymphoma liver

Deepali Jain, M.D.
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Cite this page: Jain D. Reactive lymphoid hyperplasia / pseudolymphoma. website. Accessed December 3rd, 2021.
Definition / general
  • Also called pseudolymphoma, may mimic lymphoma (Mod Pathol 2010;23:244, Am J Surg Pathol 1999;23:302)
  • Rare, < 50 cases reported
  • Age range 15 - 81 years; female predominance
  • Usually incidental finding, right lobe predilection
  • Associated with chronic liver disease, extrahepatic autoimmune disorders and malignancies
  • May be concomitant hepatic and pancreatic involvement (Clin Res Hepatol Gastroenterol 2012;36:e71)
  • May be immune mediated
  • No associated systemic manifestations
  • Resection is curative
Case reports
Gross description
  • Well circumscribed, tan, nonencapsulated, solitary (multiple in 20%) rubbery nodule, 0.5 - 5.5 cm
Microscopic (histologic) description
  • Prominent lymphoid follicles with germinal centers, tingible body macrophages and polymorphic small lymphocytes
Positive stains
Negative stains
  • BCL2 does not stain germinal centers; no light chain restriction
Differential diagnosis
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