Mesenchymal tumors

Endometrial stromal sarcoma

Last author update: 1 June 2016
Last staff update: 5 June 2023

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PubMed Search: Endometrial stromal sarcoma [title] ovary

Nalini Gupta, M.D.
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Cite this page: Gupta N. Endometrial stromal sarcoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/ovarytumoress.html. Accessed February 22nd, 2024.
Definition / general
  • Composed of cells resembling endometrial stromal cells in the proliferative stage
  • Rare in extra-uterine sites
  • Most common site is uterus
  • Extrauterine sites rare - includes ovary, fallopian tube, pelvic cavity, abdominal cavity, and retroperitoneum (Int J Gynecol Pathol 1993;12:282)
Clinical features
Radiology description
  • Ultrasound / USG: solid cystic mass
  • CT scan with IV contrast: peripheral enhancement
Prognostic factors
Case reports
  • Salphingo-opherectomy
Gross description
Microscopic (histologic) description
  • High or low grade
  • Low grade: infiltrative and diffuse proliferation of uniform round or oval cells, abundant small vessels
  • Undifferentiated: pleomorphic round / oval to spindled cells, high mitotic rate, necrosis
Microscopic (histologic) images

AFIP images
Endometrioid stromal sarcoma Endometrioid stromal sarcoma

Endometrioid stromal sarcoma

With sex cord-like differentiation

Reticulin stain

Metastatic to omentum

Images hosted on other servers:

High grade tumor

Monotonous cells

Endometrium-like glands


Positive stains
Negative stains
Differential diagnosis
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