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Ovary

Mesenchymal tumors

Endometrial stromal sarcoma

Author: Nalini Gupta, M.D.

Last author update: 1 June 2016

Last staff update: 5 June 2023

Copyright: 2003-2023, PathologyOutlines.com, Inc.

PubMed Search: Endometrial stromal sarcoma [title] ovary

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Table of Contents

Cite this page: Gupta N. Endometrial stromal sarcoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/ovarytumoress.html. Accessed June 9th, 2023.

Definition / general

Composed of cells resembling endometrial stromal cells in the proliferative stage
Rare in extra-uterine sites

Sites

Most common site is uterus
Extrauterine sites rare - includes ovary, fallopian tube, pelvic cavity, abdominal cavity, and retroperitoneum (Int J Gynecol Pathol 1993;12:282)

Clinical features

Lower abdominal pain
20 to 76 years, mean average, 54 years (Cancer 1984;53:1143)

Radiology description

Ultrasound / USG: solid cystic mass
CT scan with IV contrast: peripheral enhancement

Prognostic factors

Behavior resembles high stage primary uterine ESS (Int J Gynecol Pathol 1993;12:282)

Case reports

18 month old infant with endometriosis associated serous borderline tumor and endometrial stromal sarcoma of the ovary (Int J Gynecol Pathol 2012;31:98)
50 year old woman with endometrial stromal sarcoma presenting as an ovarian cyst (SEAJCRR 2013;2:139)
56 year old woman with undifferentiated endometrial sarcoma of ovary (Patholog Res Int 2010;2010:608519)

Treatment

Salphingo-opherectomy

Gross description

Solid cystic mass (SEAJCRR 2013;2:139)

Microscopic (histologic) description

High or low grade
Low grade: infiltrative and diffuse proliferation of uniform round or oval cells, abundant small vessels
Undifferentiated: pleomorphic round / oval to spindled cells, high mitotic rate, necrosis

Microscopic (histologic) images

AFIP images