Salivary glands

Primary salivary gland neoplasms


Lymphoepithelial carcinoma

Topic Completed: 1 September 2012

Minor changes: 13 July 2021

Copyright: 2003-2021,, Inc.

PubMed Search: lymphoepithelial carcinoma salivary [title]

Adriana Handra-Luca, M.D., Ph.D.
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Cite this page: Handra-Luca A. Lymphoepithelial carcinoma. website. Accessed December 4th, 2021.
Definition / general
  • Undifferentiated carcinoma common / familial in Eskimos and Chinese; presents as unilateral mass of parotid gland, submandibular gland or minor salivary glands in adults
Clinical features
  • May be associated with uterine lymphoepithelioma-like carcinoma
  • Metastases common to regional lymph nodes; distant metastases to liver, lung, bone
  • Treatment with surgery and radiotherapy; relatively good outcome (Br J Radiol 2006;79:52)
Case reports
Microscopic (histologic) description
  • Malignant epithelial islands resembling nonkeratinizing large cell carcinoma and lymphoid tissue with germinal centers
  • Occasional spindled areas
  • Often perineurial invasion
  • May have starry sky pattern, granuloma, amyloid; no benign lymphoepithelial lesion
Negative stains
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