Disordered proliferative

Topic Completed: 1 November 2011

Minor changes: 5 August 2020

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PubMed search: disordered proliferative endometrium

Nat Pernick, M.D.
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Cite this page: Pernick N. Disordered proliferative. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/uterusdisorderedproliferative.html. Accessed August 8th, 2020.
Definition / general
  • Associated with anovulatory cycles, exogenous estrogen therapy; common in perimenopausal and menopausal women
  • Difficult to make this diagnosis on biopsy
  • Sternberg indicates this diagnosis is "insufficient for diagnosis of hyperplasia," although WHO calls it a form of simple hyperplasia
Microscopic (histologic) description
  • Reflects unopposed estrogen stimulation (i.e. no subsequent progesterone stimulation)
  • Resembles normal exuberant proliferative endometrium, but without uniform glandular development (some glands cystically dilated, others have shallow budding)
  • Increase of cystically dilated glands, but relatively normal ratio of glands to stroma
  • Part of a continuum with endometrial hyperplasia
  • Metaplastic changes (ciliated epithelium) are common
  • May see endometrial breakdown and hemorrhage with thrombosed, thin walled vessels
  • Often plasma cells, but no clinical evidence of infection (Hum Pathol 2007;38:581)
Microscopic (histologic) images

Images hosted on other servers:

Scattered cystically
dilated glands
but a low gland density

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