Cartilaginous tumors other than chondrosarcoma
Chondromyxoid fibroma

Author: Nat Pernick, M.D. (see Authors page)

Revised: 2 December 2016, last major update August 2013

Copyright: (c) 2003-2016,, Inc.

PubMed Search: Chondromyxoid fibroma
Cite this page: Chondromyxoid fibroma. website. Accessed December 15th, 2018.
Definition / general
  • Extremely rare benign bone tumor arising in young adults
  • Age 15 - 25 years, no gender preference
  • Presents with dull, achy pain
  • Site: metaphysis of long tubular bones, small bones of feet or any bone, skull base (clivus)
Radiology description
  • Extremely well circumscribed, lytic defect with scalloped, sclerotic margin similar to metaphyseal fibrous defect
Radiology images

Images hosted on Pathout server:

Metatarsal xray - contributed by Dr. Mark R. Wick

Femur xray - contributed by Dr. Mark R. Wick

Tibia xray - contributed by Dr. Mark R. Wick

Tibial metaphysis

Distal portion of fibula

  • Benign, 25% recur after curettage
  • Fewer recurrences after en bloc excision
  • May erode through cortex but no distant metastases (Am J Surg Pathol 1979;3:363)
Case reports
Gross description
  • 3 - 8 cm, well circumscribed, solid, glistening, yellow-white-tan, lobulated, zonation, "old" tumor more hyalinized
  • Resembles hyaline cartilage
  • No myxoid change
Gross images

Images hosted on Pathout server:

Grossly lobular

Microscopic (histologic) description
  • Well circumscribed, hypocellular lobules of poorly formed hyaline cartilage composed of chondroblasts with abundant pink cytoplasm and myxoid tissue with fibrous septae containing spindle cells and osteoclasts
  • More cellular at periphery of nodules
  • Tumor cells present in lacunae in myxoid areas, stellate in myxoid areas with long delicate cell processes that approach other cells
  • Atypia is common, including large, hyperchromatic nuclei
  • Scattered calcification and osteoclast-like giant cells, although fewer giant cells in old tumors
  • Extensive vascularity is present in peripheral areas
  • No / rare mitotic activity
Microscopic (histologic) images

Images hosted on Pathout server:

Case of the Week #280

Case of the Week #280

Contributed by Dr. Mark R. Wick

Foot - contributed by Dr. Mark R. Wick

Tumor abutting irregular, thickened trabeculae

Small myxoid lobule

Fibrous septum

Curetted nodules

Cells in myxoid matrix

Cellular areas

Chondroblastoma-like area

Images hosted on other servers:

Quiz case

Positive stains
Negative stains
Molecular / cytogenetics description
Electron microscopy description
  • Myofibroblasts, chondrocytes and cells with features of both
Differential diagnosis