Bone & joints
Other chondrogenic tumors
Chondromyxoid fibroma

Topic Completed: 1 August 2013

Minor changes: 29 October 2019

Copyright: 2003-2019,, Inc.

PubMed Search: Chondromyxoid fibroma

Nat Pernick, M.D.
Page views in 2019: 9,072
Page views in 2020 to date: 5,184
Cite this page: Pernick N. Chondromyxoid fibroma. website. Accessed August 14th, 2020.
Definition / general
  • Extremely rare benign bone tumor arising in young adults
  • Age 15 - 25 years, no gender preference
  • Presents with dull, achy pain
  • Site: metaphysis of long tubular bones, small bones of feet or any bone, skull base (clivus)
Radiology description
  • Extremely well circumscribed, lytic defect with scalloped, sclerotic margin similar to metaphyseal fibrous defect
Radiology images

AFIP images

Tibial metaphysis

Distal portion of fibula

Contributed by Dr. Mark R. Wick

Metatarsal xray

Femur xray

Tibia xray

  • Benign, 25% recur after curettage
  • Fewer recurrences after en bloc excision
  • May erode through cortex but no distant metastases (Am J Surg Pathol 1979;3:363)
Case reports
Gross description
  • 3 - 8 cm, well circumscribed, solid, glistening, yellow-white-tan, lobulated, zonation, "old" tumor more hyalinized
  • Resembles hyaline cartilage
  • No myxoid change
Gross images

AFIP images

Grossly lobular

Microscopic (histologic) description
  • Well circumscribed, hypocellular lobules of poorly formed hyaline cartilage composed of chondroblasts with abundant pink cytoplasm and myxoid tissue with fibrous septae containing spindle cells and osteoclasts
  • More cellular at periphery of nodules
  • Tumor cells present in lacunae in myxoid areas, stellate in myxoid areas with long delicate cell processes that approach other cells
  • Atypia is common, including large, hyperchromatic nuclei
  • Scattered calcification and osteoclast-like giant cells, although fewer giant cells in old tumors
  • Extensive vascularity is present in peripheral areas
  • No / rare mitotic activity
Microscopic (histologic) images

Case of the Week #280

AFIP images

Tumor abutting irregular, thickened trabeculae

Small myxoid lobule

Fibrous septum

Curetted nodules

Cells in myxoid matrix

Cellular areas

Chondroblastoma-like area

Contributed by Dr. Mark R. Wick


Images hosted on other servers:

Quiz case

Positive stains
Negative stains
Molecular / cytogenetics description
Electron microscopy description
  • Myofibroblasts, chondrocytes and cells with features of both
Differential diagnosis
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