Breast malignant, males, children
Carcinoma subtypes
Cribriform carcinoma - invasive

Author: Monika Roychowdhury, M.D. (see Authors page)

Revised: 26 December 2016, last major update October 2012

Copyright: (c) 2001-2016,, Inc.

PubMed search: cribriform carcinoma [title] breast invasive

Cite this page: Cribriform carcinoma - invasive. website. Accessed October 16th, 2018.
Definition / general
  • Invasive tumor with cribriform pattern similar to cribriform DCIS
  • May have minor (< 50%) component of tubular carcinoma
Clinical features
  • Rare (1% - 3% of breast carcinomas), related to tubular carcinoma (Histopathology 1983;7:525)
  • Nodal metastases in 14%
  • Mixed patterns have intermediate prognosis between invasive cribriform and invasive ductal carcinomas
Prognostic factors
Case reports
Microscopic (histologic) description
  • Low grade, cribriform appearance (well defined spaces formed by arches of cells) similar to cribriform DCIS but with larger cells, more cytoplasm and more vesicular nuclei
  • Tumor cells are small, often have apical snouts, mild / moderate nuclear pleomorphism
  • Also stromal invasion by islands of cells, often angulated
  • May have predominantly solid appearance
  • Associated with cribriform DCIS
  • Often mixed with tubular carcinoma
  • No / rare mitotic figures, no mucin production
  • Note: pure pattern is defined as 90%+ cribriform; also considered "classic" even if minor component of tubular carcinoma
Microscopic (histologic) images
Images hosted on PathOut server:

Extensive secondary lumen
formation with angular
clusters of tumor cells

Images hosted on other servers:

Various images

Perineural invasion

Luminal micro-

Low grade nuclei

Cytology description
Positive stains
Electron microscopy description
Differential diagnosis