Colon tumor
Carcinoma
Signet ring cell carcinoma


Topic Completed: 1 August 2015

Revised: 28 June 2019

Copyright: 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: "Signet ring cell carcinoma" colon

Raul S. Gonzalez, M.D.
Page views in 2018: 8,643
Page views in 2019 to date: 6,425
Cite this page: Gonzalez R. Signet ring cell carcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/colontumorsignetring.html. Accessed July 22nd, 2019.
Definition / general
Terminology
  • Sometimes called "linitis plastica," but this typically refers to signet ring cell carcinoma of stomach
Epidemiology
Sites
  • Can occur anywhere in colon, though rectum is a less common location
Etiology
Clinical features
Diagnosis
Prognostic factors
Case reports
Clinical images

Images hosted on other servers:

Pedunculated polyp

Stenotic rectal carcinoma

Polyp in proximal sigmoid colon

Discolored lesion

Gross description
  • May diffusely infiltrate colon wall, rather than forming an exophytic mass
  • Can rarely arise within a polyp
Microscopic (histologic) description
  • Proliferation of signet ring cells with intracellular mucin that displaces nucleus to side
  • Pools of extracellular mucin often present as well
  • Diffuse tissue infiltration less common than in gastric signet ring cell carcinoma
  • May rarely be in situ or confined to a polyp (J Surg Res 2010;163:250)
  • No gland formation in signet ring cell component, although it may be present elsewhere in the same lesion
Microscopic (histologic) images

Images hosted on other servers:

Numerous mucinous pools

Signet ring cells floating

Signet ring cell carcinoma

Multilobulation

For comparison,
normal colonic
glands with signet
ring cells, CK7

Negative stains
Molecular / cytogenetics description
Differential diagnosis
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