Prostatic carcinoma variants
Intraductal carcinoma

Authors: Nat Pernick, M.D. (see Authors page)

Revised: 9 August 2016, last major update October 2013

Copyright: (c) 2002-2016,, Inc.

PubMed search: prostatic intraductal carcinoma
Cite this page: Intraductal carcinoma. website. Accessed October 26th, 2016.
Definition / General
Case Reports
  • 58 year old man with hypertension presented with urinary frequency, urgency and nocturia (Case of the Week #286)
Micro Description
  • Uncommon biopsy finding
  • Defined by Epstein et. al. as malignant epithelial cells filling large acini and prostatic ducts, with intact basal cells, in either: (1) solid or dense cribriform patterns or (2) loose cribriform or micropapillary patterns with either marked nuclear atypia (nuclear size 6 x normal or larger) or comedonecrosis (Mod Pathol 2006;19:1528)
  • More than one pattern is usually present
  • Presence of basal cells can be confirmed by CK903 or p63 immunostains
Micro Images

Images hosted on PathOut server:

Various images (left 2: H&E; right 2: CK903)

Images hosted on other servers:

Morphologic subtypes

Various images

p63 and AMACR


Differential Diagnosis