Prostatic carcinoma variants
Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 10 October 2013, last major update October 2013
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.
- 58 year old man with hypertension presented with urinary frequency, urgency and nocturia (Case of the Week #286)
- Uncommon biopsy finding
- Defined by Epstein et. al. as malignant epithelial cells filling large acini and prostatic ducts, with intact basal cells, in either: (1) solid or dense cribriform patterns or (2) loose cribriform or micropapillary patterns with either marked nuclear atypia (nuclear size 6 x normal or larger) or comedonecrosis (Mod Pathol 2006;19:1528)
- More than one pattern is usually present
- Presence of basal cells can be confirmed by CK903 or p63 immunostains
End of Prostate > Other carcinomas > Intraductal carcinoma
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