Prostate - Stromal proliferation of uncertain malignant potential

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Prostate

Other malignancies

Stromal proliferation of uncertain malignant potential

Reviewers: Komal Arora, M.D., (see Reviewers page)
Revised: 15 March 2013, last major update July 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
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Rare prostatic tumors characterized by atypical stromal proliferation
May resemble breast phyllodes tumors
May recur rapidly after resection and progress to stromal sarcoma

Case reports
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34 year old man with death due to lung metastases (Rare Tumors 2010;2:e57)
56 year old man with recurrent tumor (Ann Acad Med Singapore 2005;34:441)
59 year old man with a PSA of 7.9 (Case of the Week #269)
67 year old man (Urologia 2012;79:65)

Gross images
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**STUMP which eventually metastasized**

**Case of the Week #269**

Micro description
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Four patterns:
1. Hypercellular stroma with scattered cytologically atypical cells associated with benign glands
2. Hypercellular stroma with minimal cytological atypia associated with benign glands
3. Hypercellular stroma, benign glands in a "leaf like" growth pattern resembling breast phyllodes tumor, variable cytologic atypia, and
4. Hypercellular stroma without cytologically atypical stromal cells and without glands (Am J Surg Pathol 1998;22:148, Am J Surg Pathol 2006;30:694)
May also have epithelial proliferations which mask diagnosis of STUMP; most comon are glandular crowding, prominent basal cell layer, prominent papillary infolding (Am J Surg Pathol 2011;35:898)

Micro images
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**STUMP which eventually metastasized**

**Various images**

Case of the Week #269:

**CD34**

**Desmin**

**HHF35**

**Ki-67**

PR

End of Prostate > Other malignancies > Stromal proliferation of uncertain malignant potential

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