Prostate
Other malignancies
Stromal proliferation of uncertain malignant potential

Authors: Komal Arora, M.D. (see Authors page)

Revised: 9 September 2016, last major update July 2012

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: stromal proliferation [title] prostate

Cite this page: Stromal proliferation of uncertain malignant potential. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/prostatestromalprolif.html. Accessed December 7th, 2016.
Definition / General
  • Rare prostatic tumors characterized by atypical stromal proliferation
  • May resemble breast phyllodes tumors
  • May recur rapidly after resection and progress to stromal sarcoma
Case Reports
Gross Images
Images hosted on PathOut server:

Case of the Week #269



Images hosted on other servers:

STUMP which eventually metastasized

Micro Description
  • Four patterns:
    • Hypercellular stroma with scattered cytologically atypical cells associated with benign glands
    • Hypercellular stroma with minimal cytological atypia associated with benign glands
    • Hypercellular stroma, benign glands in a "leaf like" growth pattern resembling breast phyllodes tumor, variable cytologic atypia, and
    • Hypercellular stroma without cytologically atypical stromal cells and without glands (Am J Surg Pathol 1998;22:148, Am J Surg Pathol 2006;30:694)
  • May also have epithelial proliferations which mask diagnosis of STUMP; most comon are glandular crowding, prominent basal cell layer, prominent papillary infolding (Am J Surg Pathol 2011;35:898)
Micro Images
Images hosted on PathOut server:

Case of the Week #269



CD34

Desmin

HHF35

Ki-67

PR



Images hosted on other servers:

56 year old man with urinary frequency, dysuria and enlarged prostate. Tissue is from TURP. Contributed by Dr. N. Hariharanadha Sarma, Batalapalli, India.



STUMP which eventually metastasized

Enlarged, degenerative-appearing cells

Hypercellular STUMP

Benign phyllodes-like STUMP

Myxoid STUMP

Various images