Stromal proliferation of uncertain malignant potential

Prostate
Other malignancies
Stromal proliferation of uncertain malignant potential

Authors: Komal Arora, M.D. (see Authors page)

Revised: 9 September 2016, last major update July 2012

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: stromal proliferation [title] prostate

Table of Contents

Definition / General | Case Reports | Gross Images | Micro Description | Micro Images

Definition / General

Rare prostatic tumors characterized by atypical stromal proliferation
May resemble breast phyllodes tumors
May recur rapidly after resection and progress to stromal sarcoma

Case Reports

34 year old man with prostatic stromal tumor with fatal outcome (Rare Tumors 2010;2:e57)
56 year old man with recurrent prostatic stromal tumour of uncertain malignant potential (Ann Acad Med Singapore 2005;34:441)
59 year old man with a PSA of 7.9 (Case of the Week #269)
67 year old man with incidental prostatic stromal tumor of uncertain malignant potential (Urologia 2012;79:65)

Gross Images

Images hosted on PathOut server:

Case of the Week #269

Images hosted on other servers:

STUMP which eventually metastasized

Micro Description

Four patterns:
- Hypercellular stroma with scattered cytologically atypical cells associated with benign glands
- Hypercellular stroma with minimal cytological atypia associated with benign glands
- Hypercellular stroma, benign glands in a "leaf like" growth pattern resembling breast phyllodes tumor, variable cytologic atypia, and
- Hypercellular stroma without cytologically atypical stromal cells and without glands (Am J Surg Pathol 1998;22:148, Am J Surg Pathol 2006;30:694)
May also have epithelial proliferations which mask diagnosis of STUMP; most comon are glandular crowding, prominent basal cell layer, prominent papillary infolding (Am J Surg Pathol 2011;35:898)

Micro Images

Images hosted on PathOut server:

Case of the Week #269

CD34

Desmin

HHF35

Ki-67

Images hosted on other servers:

56 year old man with urinary frequency, dysuria and enlarged prostate. Tissue is from TURP. Contributed by Dr. N. Hariharanadha Sarma, Batalapalli, India.

STUMP which eventually metastasized

Enlarged, degenerative-appearing cells

Hypercellular STUMP

Benign phyllodes-like STUMP

Myxoid STUMP

Various images