General
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• Rare prostatic tumors characterized by atypical stromal proliferation
• May resemble breast phyllodes tumors
• May recur rapidly after resection and progress to stromal sarcoma

Case reports
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• 34 year old man with prostatic stromal tumor with fatal outcome (Rare Tumors 2010;2:e57)
• 56 year old man with recurrent prostatic stromal tumour of uncertain malignant potential (Ann Acad Med Singapore 2005;34:441)
• 59 year old man with a PSA of 7.9 (Case of the Week #269)
• 67 year old man with incidental prostatic stromal tumor of uncertain malignant potential (Urologia 2012;79:65)

Gross images
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STUMP which eventually metastasized

Case of the Week #269

Micro description
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• Four patterns:
  1. Hypercellular stroma with scattered cytologically atypical cells associated with benign glands
  2. Hypercellular stroma with minimal cytological atypia associated with benign glands
  3. Hypercellular stroma, benign glands in a "leaf like" growth pattern resembling breast phyllodes tumor, variable cytologic atypia, and
  4. Hypercellular stroma without cytologically atypical stromal cells and without glands (Am J Surg Pathol 1998;22:148, Am J Surg Pathol 2006;30:694)
• May also have epithelial proliferations which mask diagnosis of STUMP; most comon are glandular crowding, prominent basal cell layer, prominent papillary infolding (Am J Surg Pathol 2011;35:898)

Micro images
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STUMP which eventually metastasized

Enlarged, degenerative-appearing cells

Hypercellular STUMP

Benign phyllodes-like STUMP

Myxoid STUMP

Various images

     

Case of the Week #269

CD34

Desmin

HHF35

Ki-67

PR

         

56 year old man with urinary frequency, dysuria and enlarged prostate. Tissue is from TURP. Contributed by Dr. N. Hariharanadha Sarma, Batalapalli, India.

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