Skin - Nonmelanocytic tumors
Vascular tumors
Epithelioid hemangioma

Author: Christopher Hale, M.D. (see Authors page)

Revised: 7 October 2016, last major update July 2012

Copyright: (c) 2003-2016,, Inc.

PubMed search: epithelioid [title] hemangioma skin

Related topics: Hemangioma

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Cite this page: Epithelioid hemangioma. website. Accessed February 19th, 2019.
Definition / general
  • Also called histiocytoid hemangioma, angiolymphoid hyperplasia with eosinophilia (ALHE)
  • All racial groups
  • Head and neck nodules, often periauricular
  • Benign in skin
  • May be reactive
  • May occur in bone
  • No / rare regional lymphadenopathy
  • Normal serum eosinophils, IgE
Case reports
Gross description
  • Small, superficial, dermal papulonodules, frequently erythematous, with bleeding
Microscopic (histologic) description
  • Proliferation of blood vessels with epithelioid endothelial cells exhibiting abundant eosinophilic cytoplasm with variable cytoplasmic vacuoles resembling intracytoplasmic lumina and large vesicular nuclei with variable atypia
  • Usually heavy infiltrate of eosinophils and lymphocytes with germinal centers
  • May have lobular solid pattern
Microscopic (histologic) images
Images hosted on PathOut server:

Courtesy of Dr. Mark R. Wick

Images hosted on other servers:

Aggregate of lymphoid tissue

Blood vessels lined by cuboidal endothelial cells

Differential diagnosis