Skin nonmelanocytic tumor
Vascular tumors
Epithelioid hemangioma / angiolymphoid hyperplasia with eosinophils


Topic Completed: 1 July 2012

Revised: 16 April 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed search: epithelioid [title] hemangioma skin

Christopher S. Hale, M.D.
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Cite this page: Hale CS. Epithelioid hemangioma / angiolymphoid hyperplasia with eosinophils. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/skintumornonmelanocytichemangiomaepithelioid.html. Accessed December 15th, 2019.
Definition / general
  • Also called histiocytoid hemangioma, angiolymphoid hyperplasia with eosinophilia (ALHE)
  • All racial groups
  • Head and neck nodules, often periauricular
  • Benign in skin
  • May be reactive
  • May occur in bone
  • No / rare regional lymphadenopathy
  • Normal serum eosinophils, IgE
Case reports
Gross description
  • Small, superficial, dermal papulonodules, frequently erythematous, with bleeding
Microscopic (histologic) description
  • Proliferation of blood vessels with epithelioid endothelial cells exhibiting abundant eosinophilic cytoplasm with variable cytoplasmic vacuoles resembling intracytoplasmic lumina and large vesicular nuclei with variable atypia
  • Usually heavy infiltrate of eosinophils and lymphocytes with germinal centers
  • May have lobular solid pattern
Microscopic (histologic) images
Images hosted on PathOut server:

Courtesy of Dr. Mark R. Wick



Images hosted on other servers:

Aggregate of lymphoid tissue

Blood vessels lined by cuboidal endothelial cells

Differential diagnosis
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