Soft tissue
Fibroblastic / myofibroblastic tumors
Pleomorphic fibroma of skin

Author: Christine E. Jabcuga, M.D. (see Authors page)
Editor: Jerad M. Gardner, M.D.

Revised: 29 August 2016, last major update June 2013

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: Pleomorphic fibroma of skin

Cite this page: Pleomorphic fibroma of skin. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/softtissuepleomorphicfibroma.html. Accessed December 2nd, 2016.
Definition / General
  • Polypoid or dome-shaped cutaneous nodule with sparse cellularity and cytologic atypia of fibroblasts
  • Not a WHO diagnosis
  • First described in 1989 (Am J Surg Pathol 1989;13:107)
  • Usually trunk, extremity or head (Clin Exp Dermatol 1998;23:22)
  • Related entities: may be a variant of skin tag (acrochordon) with cytologic atypia
Clinical Features
  • Flesh-colored polyp resembling skin tag (acrochordon)
Case Reports
Micro Description
Micro Images

Images hosted on PathOut servers:

AFIP: large pleomorphic
cells separated by collagen

AFIP: atypical cells have smudged chromatin,
mitoses are absent / rare, compare to sarcomas
with abnormal (but not degenerative) nuclei
and frequent mitotic figures, some atypical




Images hosted on other servers:

Anal skin

Stromal cells have atypical nuclei

Various images

Cytology Description
  • Single lying and few clusters of pleomorphic cells with some monster cells and scant cytoplasm (J Cytol 2013;30:71)
Cytology Images

Images hosted on other servers:

Pleomorphic cells with very large nuclei

Pleomorphic cells scattered between collagen bundles

Vimentin+

Positive Stains
Differential Diagnosis