Soft tissue
Fibroblastic / myofibroblastic
Pleomorphic fibroma of skin

Topic Completed: 1 June 2013

Minor changes: 14 December 2019

Copyright: 2002-2018,, Inc.

PubMed Search: Pleomorphic fibroma of skin

Christine E. Jabcuga, M.D.
Jerad M. Gardner, M.D.
Page views in 2019: 1,609
Page views in 2020 to date: 802
Cite this page: Jabcuga C. Pleomorphic fibroma of skin. website. Accessed August 3rd, 2020.
Definition / general
  • Polypoid or dome-shaped cutaneous nodule with sparse cellularity and cytologic atypia of fibroblasts
  • Not a WHO diagnosis
  • First described in 1989 (Am J Surg Pathol 1989;13:107)
  • Usually trunk, extremity or head (Clin Exp Dermatol 1998;23:22)
  • Related entities: may be a variant of skin tag (acrochordon) with cytologic atypia
Clinical features
  • Flesh-colored polyp resembling skin tag (acrochordon)
Case reports
Microscopic (histologic) description
Microscopic (histologic) images

Images hosted on PathOut servers:

AFIP: large pleomorphic
cells separated by collagen

AFIP: atypical cells have smudged chromatin,
mitoses are absent / rare, compare to sarcomas
with abnormal (but not degenerative) nuclei
and frequent mitotic figures, some atypical

Images hosted on other servers:

Anal skin

Stromal cells have atypical nuclei

Various images

Cytology description
  • Single lying and few clusters of pleomorphic cells with some monster cells and scant cytoplasm (J Cytol 2013;30:71)
Cytology images

Images hosted on other servers:

Pleomorphic cells with very large nuclei

Pleomorphic cells scattered between collagen bundles


Positive stains
Differential diagnosis
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