Skin nonmelanocytic tumor
Fibrous, fibrohistiocytic and myofibroblastic neoplasms
Pleomorphic fibroma


Topic Completed: 1 June 2013

Minor changes: 1 October 2020

Copyright: 2002-2020, PathologyOutlines.com, Inc.

PubMed Search: Pleomorphic fibroma of skin

Christine E. Jabcuga, M.D.
Jerad M. Gardner, M.D.
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Cite this page: Jabcuga C. Pleomorphic fibroma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/softtissuepleomorphicfibroma.html. Accessed October 26th, 2020.
Definition / general
  • Polypoid or dome-shaped cutaneous nodule with sparse cellularity and cytologic atypia of fibroblasts
  • Not a WHO diagnosis
  • First described in 1989 (Am J Surg Pathol 1989;13:107)
  • Usually trunk, extremity or head (Clin Exp Dermatol 1998;23:22)
  • Related entities: may be a variant of skin tag (acrochordon) with cytologic atypia
Clinical features
  • Flesh-colored polyp resembling skin tag (acrochordon)
Case reports
Microscopic (histologic) description
Microscopic (histologic) images

AFIP images
Large pleomorphic cells

Large pleomorphic cells

Atypical cells

Atypical cells



Images hosted on other servers:
Anal skin

Anal skin

Stromal cells have atypical nuclei

Stromal cells have atypical nuclei

Cytology description
  • Single lying and few clusters of pleomorphic cells with some monster cells and scant cytoplasm (J Cytol 2013;30:71)
Cytology images

Images hosted on other servers:
Pleomorphic cells with very large nuclei

Pleomorphic cells with very large nuclei

Pleomorphic cells scattered between collagen bundles

Pleomorphic cells
scattered between
collagen bundles

Vimentin+

Vimentin+

Positive stains
Differential diagnosis
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