Thyroid gland
Other malignancies

Topic Completed: 1 January 2015

Minor changes: 18 March 2019

Copyright: 2016-2017,, Inc.

PubMed Search: plasmacytoma thyroid

Sheren Younes, M.D.
Page views in 2019: 288
Page views in 2020 to date: 199
Cite this page: Younes S. Plasmacytoma. website. Accessed August 6th, 2020.
Definition / general
  • Rare tumor of thyroid gland, presenting as a mass
  • Solitary or associated with multiple myeloma
  • Diagnosis should be restricted to tumors without a lymphoid component
Case reports
Gross images

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Gray, firm, fleshy

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Thyroidectomy specimen

Microscopic (histologic) description
  • Dense infiltrate of plasma cells replacing thyroid follicles
  • Plasma cells often appear monotonous; may be mature, immature or anaplastic
  • Mature plasma cells: basophilic cytoplasm and clock face nucleus
  • Immature plasma cells: large irregular nuclei, less condensed chromatin and occasional nucleoli
  • Anaplastic plasma cells: significant variation of nuclear size, coarse to vesicular nuclei and prominent nucleoli
  • Also multinucleated cells, immunoglobulin inclusions (dutcher bodies or intracytoplasmic crystals)
Microscopic (histologic) images

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Case of the Week #394:








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Mature and immature plasma cells

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H&E, CD138+

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(A) Kappa light chain+
(B) Lambda light chain-

Cytology description
  • Cellular; single cell infiltrates with basophilic cytoplasm containing paranuclear hof, round / oval nuclei with cartwheel chromatin, variable pleomorphism, multinucleation
Cytology images

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Intranuclear inclusion

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Congo red+

Positive stains
Negative stains
Differential diagnosis
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