Bladder, ureter & renal pelvis

Other nonneoplastic

Postoperative spindle cell nodule

Last author update: 1 December 2014
Last staff update: 12 November 2021

Copyright: 2003-2023,, Inc.

PubMed Search: Postoperative spindle cell nodule [title]

Monika Roychowdhury, M.D.
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Cite this page: Roychowdhury M. Postoperative spindle cell nodule. website. Accessed September 21st, 2023.
Definition / general
  • Usually women
Clinical features
  • Sometimes incidental
  • May present with hematuria or obstructive voiding symptoms
Prognostic factors
  • Excellent prognosis
Gross description
  • Friable nodule, mean size 1 cm
Microscopic (histologic) description
  • Cellular, fascicular growth pattern of plump or elongated spindle cells which infiltrate the bladder wall and may focally destroy muscle
  • Delicate network of small blood vessels in edematous or myxoid stroma with red blood cell extravasation
  • Ulcerated surface with acute and chronic inflammatory infiltrate
  • May show low to high mitotic activity but no atypical mitotic figures, resembles sarcoma but no atypia
  • No necrosis, no significant pleomorphism
Microscopic (histologic) images

AFIP images

Interlacing fascicles of myofibroblasts

Uniform cells are mixed with inflammatory cells

Images hosted on other servers:

Left: muscularis
Right: spindle
cell nodule

Cytology description
Positive stains
Negative stains
Molecular / cytogenetics description
Differential diagnosis
  • Kaposi sarcoma:
    • No history of recent procedure, primarily a vascular tumor
  • Myxoid leiomyosarcoma:
    • No history of recent procedure; has smooth muscle morphology, pleomorphism, atypical mitotic figures, necrosis
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