Breast
Fibrocystic changes
Fibrosis
Author: Hind Warzecha, M.D.
Last author update: 1 June 2010
Last staff update: 17 November 2020
Copyright: 2002-2019, PathologyOutlines.com, Inc.
PubMed Search: Fibrosis [title] breast [title]
Table of Contents
Definition / general | Terminology | Epidemiology | Etiology | Clinical features | Treatment | Gross images | Microscopic (histologic) description | Microscopic (histologic) imagesCite this page: Warzecha H. Fibrosis. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/breastfibrosis.html. Accessed September 30th, 2023.
Definition / general
- Variable increase in dense connective tissue
Terminology
- Also called hyaline fibrosis of stroma
Epidemiology
- Common finding (2 - 7% of core needle biopsies, Radiology 2000;216:255, AJR Am J Roentgenol 2001;177:573)
Etiology
- Unknown
- Associated with diabetes (Gen Diagn Pathol 1997;143:49), radiation therapy (Eur J Cancer 2008;44:2587), Cowden syndrome (Exp Dermatol 1998;7:380)
Clinical features
- Nonspecific finding
- May be associated with a reduced risk for progression to breast cancer (Clin Cancer Res 2007;13:5474)
Treatment
- Does not require specific therapy
Gross images
Contributed by Dr. Mark R. Wick
Stroma
Images hosted on other servers:
Fibrosis
Microscopic (histologic) description
- Fibrous stromal proliferation with obliteration of ducts and acini
Microscopic (histologic) images
Contributed by Dr. Mark R. Wick
Stroma
Images hosted on other servers:
Mass-like fibrosis with entrapped ducts and lobules
H&E
