Breast
Other benign tumors
Leiomyoma
Author: Hind Warzecha, M.D.
Last author update: 1 April 2010
Last staff update: 28 September 2023 (update in progress)
Copyright: 2002-2023, PathologyOutlines.com, Inc.
PubMed Search: Leiomyoma [title] breast
Table of Contents
Definition / general | Epidemiology | Sites | Etiology | Clinical features | Case reports | Treatment | Clinical images | Gross description | Microscopic (histologic) description | Microscopic (histologic) images | Positive stains | Negative stains | Differential diagnosisCite this page: Warzecha H. Leiomyoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/breastleiomyoma.html. Accessed September 30th, 2023.
Definition / general
- Benign smooth muscle tumor similar to counterparts elsewhere
Epidemiology
- Rare in breast
Sites
- Usually involves nipple
Etiology
- Usually contiguous with muscular components of nipple areolar complex (J La State Med Soc 1998;150:367)
Clinical features
- Superficial or deep (vascular)
- Often painful (Am J Surg Pathol 1979;3:151)
Case reports
- 23 year old woman with hyperkeratotic subareolar leiomyoma (Ann Dermatol Venereol 2008;135:571)
- 42 year old woman with epithelioid leiomyoma with granular cell change (Hum Pathol 1993;24:1260)
- 47 year old woman with tumor of breast parenchyma (AJR Am J Roentgenol 2005;185:1595)
- Tumor of nipple (Breast J 2006;12:377)
Treatment
- Complete excision to prevent recurrence
Clinical images
Contributed by Dr. Mark R. Wick
Breast skin
Gross description
- Often ill defined
Microscopic (histologic) description
- Interlacing bundles of spindle cells with eosinophilic cytoplasm and blunt ended, cigar shaped nuclei
- May have epithelioid or granular features
- No atypia, no hypercellularity, no / rare mitotic figures ( < 3 per 10 HPF), no necrosis
Microscopic (histologic) images
AFIP images
Circumscribed tumor of spindled cells without atypia
Contributed by Dr. Mark R. Wick
Breast skin
Positive stains
Differential diagnosis
- Hamartoma:
- Also adipose and epithelial elements
- Leiomyosarcoma:
- Infiltrating tumor with pleomorphism, atypia, necrosis (Diagn Pathol 2006;1:13)
