Fallopian tubes & broad ligament

Broad ligament

Walthard cell nests

Topic Completed: 1 September 2013

Minor changes: 3 September 2021

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PubMed Search: Walthard cell nests

Nicole Riddle, M.D.
Jamie Shutter, M.D.
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Cite this page: Riddle N, Shutter J. Walthard cell nests. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/fallopiantubeswalthard.html. Accessed October 25th, 2021.
Definition / general
  • Benign epithelial cell clusters found in perifallopian tube tissue
  • Also called transitional / urethelial cell metaplasia
  • May be found anywhere in broad ligament, including ovarian hilum
  • May be source of Brenner tumors or primary urethelial cell carcinomas (parafallopian tube transitional cell carcinoma) (Gynecol Oncol 2002;86:379)
Gross description
  • May be white / yellow nodules or cysts up to 2 mm
  • Often an incidental microscopic finding
Gross images

AFIP images

Several small yellow
nodules clustered on
serosa of isthmic
portion of tube

Microscopic (histologic) description
  • Well circumscribed, small, round collections of flat to cuboidal cells with minimal atypia
  • Elliptical nuclei with prominent nuclear grooves, 1 - 2 small nucleoli
  • May see inspissated eosinophilic secretion or mucin within lumina
  • No / rare mitotic figures
Microscopic (histologic) images

AFIP images

Walthard nests

Images hosted on other servers:

Warthard cell nests at lower right

Note "coffee bean" nuclei

Positive stains
  • CK7, involucrin
Negative stains
Differential diagnosis
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