Brenner tumors
Benign Brenner tumor

Topic Completed: 1 December 2012

Minor changes: 19 October 2020

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PubMed Search: ovarian benign Brenner tumor

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Cite this page: Ehdaivand S. Benign Brenner tumor. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/ovarytumorb9brenner.html. Accessed January 18th, 2021.
Definition / general
  • Derived from ovarian surface epithelium and metaplasia; similar to Walthard nests
  • 6% bilateral
Gross description
  • Unilateral, firm, white / yellow
  • Resembles fibroma / thecoma except for cystic areas with yellow-brown fluid
Gross images

AFIP images

Sharply demarcated

Fibroma-like appearance

Solid fibroma-like component and two cysts

Images hosted on other servers:

Infarcted tumor

Microscopic (histologic) description
  • Solid and cystic nests of urothelium-like cells surrounded by abundant dense, fibrous stroma
  • Epithelial cells have sharp outlines
  • Cells are uniform, polygonal with pale cytoplasm, small but distinct nucleoli, often grooved nuclei (similar to granulosa cell tumors)
  • Frequent microcysts within epithelial nests
  • Metaplastic: with prominent cystic formation, accompanied by florid mucinous changes similar to cystitis glandularis
  • Proliferating: with papillary pattern and low grade nuclear atypia resembling low grade urothelial carcinoma of bladder (some authors consider this type of Brenner tumor to be borderline, Cancer 1985;56:582)
Microscopic (histologic) images

AFIP images

Fibromatous stromal component

Resembling coffee beans

Several lumens

Mucinous epithelium

Ciliated epithelium

Images hosted on other servers:

"Coffee-bean" appearance


Brenner tumor
Positive stains
Negative stains
  • CK20
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