Gallbladder & extrahepatic bile ducts
Extrahepatic bile duct tumors
Biliary intraepithelial neoplasia

Topic Completed: 1 September 2012

Minor changes: 13 September 2019

Copyright: 2003-2019,, Inc.

PubMed Search: Extrahepatic bile ducts biliary intraepithelial neoplasia

Hanni Gulwani, M.B.B.S.
Page views in 2019: 3,049
Page views in 2020 to date: 2,058
Cite this page: Gulwani H. Biliary intraepithelial neoplasia. website. Accessed August 14th, 2020.
Definition / general

  • Flat or micropapillary, basal nuclei, pseudostratification (within lower two thirds of epithelium)
  • Mild nuclear abnormalities

  • Flat, pseudopapillary or micropapillary architecture
  • Loss of cellular polarity
  • Pseudostratification (reaching the luminal surface), dysplastic nuclear changes
  • Peribiliary glands are sometimes involved
  • Mitoses are rare

  • Pseudopapillary or micropapillary architecture
  • Cytologically resembles carcinoma but no invasion
  • 'Budding off' of small clusters of epithelial cells
  • Severe nuclear membrane irregularities
Differential diagnosis
  • Hyperplasia or regenerative change: flat or low papillae, nuclear membrane smooth with fine chromatin, intraepithelial neutrophil infiltration can be seen; variable mitotic figures
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