Cite this page: Sangle N. MDS / MPN - unclassifiable. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/myeloproliferativemdsmpnunclassified.html. Accessed January 24th, 2021.
Definition / general
- This is a provisional myelodysplasia / myeloproliferative disorder (Haematologica 2008;93:34, Blood 2006;108:2173), with JAK2 V617F mutation present in 48 - 67%
- Diagnostic criteria: features of one of the myelodysplasia / myeloproliferative categories but no history of MDS/MPN, no history of growth factor or cytotoxic therapy, no BCR-ABL1 gene fusion, no rearrangement of PDGFRA, PDGFRB or FGFR1, no del(5q), no inv(3)(q21;q26) OR de novo disease with MPN and MDS features which cannot be assigned to any specific category of MDS/MPN
- Includes refractory anemia with ringed sideroblasts (RARS) with dyserythropoiesis and marked thrombocytosis (RARS-T) with megakaryocytes similar to those in ET, PV or primary myelofibrosis