Skin nonmelanocytic tumor

Vascular tumors

Capillary / pyogenic granuloma



Topic Completed: 1 August 2012

Minor changes: 8 October 2021

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PubMed search: pyogenic [title] granuloma skin

Christopher S. Hale, M.D.
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Cite this page: Hale CS. Capillary / pyogenic granuloma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/skintumornonmelanocyticpyogenicgranuloma.html. Accessed October 16th, 2021.
Definition / general
  • Very common; rapidly growing polypoid red mass surrounded by thickened epidermis, often in finger or lips
  • Also called granuloma pyogenicum, lobular capillary hemangioma
  • May be associated with keratinous cyst
  • Benign, often regresses spontaneously
  • May be disseminated, occur within port wine stains, be in deep dermis / subcutis or be intravenous

Variants:
  • Classic polypoid, dermal, subcutaneous, intravenous, eruptive, with multiple satellites
Treatment
  • None or excision (may recur as multiple satellites)
Clinical images

Contributed by Mark R. Wick, M.D.

Pyogenic granuloma

Gross description
  • Fleshy cutaneous tumor
Microscopic (histologic) description
  • Lobular pattern of vascular proliferation with inflammation and edema resembling granulation tissue
  • Thin epidermis at top with variable ulceration
  • Acanthosis and hyperkeratosis at sides
  • Central branching vessel is called capillary or vascular lobule, with no / rare red blood cells, surrounded by endothelial cells
  • Variable mitotic activity
  • Deep lesions often lack edema and inflammation
Microscopic (histologic) images

Contributed by Mark R. Wick, M.D.

Pyogenic granuloma



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Differential diagnosis
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