Soft tissue
Adipose tissue tumors
Lipoma and variants

Topic Completed: 1 August 2012

Minor changes: 21 January 2021

Copyright: 2002-2021,, Inc.

PubMed Search: Angiolipoma

Vijay Shankar, M.D.
Page views in 2020: 12,170
Page views in 2021 to date: 5,282
Cite this page: Shankar, V. Angiolipoma. website. Accessed May 7th, 2021.
Definition / general
  • Subcutaneous nodule composed of mature adipocytes, thin walled vessels and fibrin thrombi
  • Arises shortly before puberty or in young adults
  • Rare in children or older adults
  • 5% familial
Clinical features
  • Usually skin, 2/3 in forearm and chest wall, can occur on thighs, distal extremity
  • Rarely in the head and neck region
  • Painful, usually multiple subcutaneous nodules (other painful nodules are angioleiomyoma, eccrine spiradenoma, glomus tumor and traumatic neuroma)
  • May actually be hemangioma containing fat, not a mixed tumors
Case reports
  • Excision
  • Does not recur or metastasize
Clinical images

Images hosted on other servers:

Soft nodular mass


Clinical featuring

Gross description
  • Encapsulated, small (< 2 cm), yellow-red nodule in subcutaneous tissue
Gross images

Images hosted on other servers:

Lesion and its microscopic appearance

Yellowish in color

Thin fibrous septae and brown spots

Microscopic (histologic) description
  • Mature adipose tissue, branching capillaries and thick walled vessels with pericytes, particularly at periphery
  • Hyaline / fibrin thrombi are an important diagnostic sign
  • Cellular tumors are usually encapsulated with septation and fibrin thrombi (Am J Surg Pathol 1990;14:75)
  • Mast cells are present
  • Fibrosis in older lesions
Microscopic (histologic) images

Contributed by Semir Vranić, M.D., Ph.D.

25 year old woman

Contributed by Mark R. Wick, M.D.

Various images

AFIP images

Mature adipose and proliferated vascular tissue

Images hosted on other servers:

Prominent vascular thrombi

9 year old girl with lesion on lip

Mature adipose and proliferated vascular tissue

Mature adipose tissue and prominent vasculature

Mature adipose and proliferated vascular tissue

Degenerative lesions of the adipose tissue

Electron microscopy description
Molecular / cytogenetics description
  • Almost always normal karyotype
Differential diagnosis
Back to top
Image 01 Image 02