Stains & molecular markers
BCL6


Topic Completed: 1 January 2012

Minor changes: 10 December 2020

Copyright: 2003-2021, PathologyOutlines.com, Inc.

PubMed Search: BCL6[title]

Nat Pernick, M.D.
Page views in 2020: 12,943
Page views in 2021 to date: 4,359
Cite this page: Pernick N. BCL6. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsbcl6.html. Accessed April 19th, 2021.
Definition / general
  • Transcription factor at 3q27 normally expressed in germinal centers and in 5 - 15% of intrafollicular CD4+ T cells
  • Protects germinal center (GC) B cells against DNA damage induced apoptosis during somatic hypermutation and class switch recombination (J Exp Med 2010;207:1209)
  • Translocations help define "double hit" lymphomas (Am J Clin Pathol 2010;134:258)
Interpretation
  • Nuclear staining
Uses by pathologists
  • Germinal center marker (also CD10)
  • Marker for follicular lymphoma (30 - 80%) of cases, can distinguish from MALT (BCL6-)
  • Double staining of CD3 and BCL6 is helpful in appreciating follicular T helper cell immunophenotype of angioimmunoblastic T cell lymphoma (Hum Pathol 2010;41:79)
Microscopic (histologic) images

Images hosted on other servers:

Follicular lymphoma: left - spleen (fig C)

Mantle cell lymphoma case is BCL6+ (uncommon)

Neuroblastoma

Germinal center associated markers

Positive staining - normal
Positive staining - disease
Negative staining
Molecular / cytogenetics description
Back to top
Image 01 Image 02