Atrophic gastritis

Topic Completed: 1 August 2012

Minor changes: 29 April 2019

Copyright: 2003-2019,, Inc.

PubMed Search: chronic (atrophic) gastritis

Elliot Weisenberg, M.D.
Page views in 2019: 10,067
Page views in 2020 to date: 5,290
Cite this page: Weisenberg E. Atrophic gastritis. website. Accessed August 8th, 2020.
Definition / general
  • Sometimes known as multifocal atrophic gastritis; formerly environmental gastritis
  • Chronic gastritis accompanied by glandular atrophy (mild, moderate, severe), usually secondary to chronic H. pylori infection
  • Initially glands are compressed, later they are destroyed, loss of acid leads to conditions conducive to bacterial growth
  • Associated with duodenal ulcer, gastric peptic ulcer
  • Degree of atrophy and intestinal metaplasia are correlated (Hum Pathol 2001;32:31)
  • Epithelial changes may become dysplastic and progress to carcinoma
Gross description
  • Thin, smooth mucosa (without rugae), prominent submucosal vessels (due to mucosal atrophy)
Microscopic (histologic) images

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Chronic atrophic gastritis with intestinal metaplasia

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