Atrophic gastritis

Last author update: 1 August 2012
Last staff update: 26 September 2023 (update in progress)

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PubMed Search: chronic (atrophic) gastritis

Elliot Weisenberg, M.D.
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Cite this page: Weisenberg E. Atrophic gastritis. website. Accessed September 30th, 2023.
Definition / general
  • Sometimes known as multifocal atrophic gastritis; formerly environmental gastritis
  • Chronic gastritis accompanied by glandular atrophy (mild, moderate, severe), usually secondary to chronic H. pylori infection
  • Initially glands are compressed, later they are destroyed, loss of acid leads to conditions conducive to bacterial growth
  • Associated with duodenal ulcer, gastric peptic ulcer
  • Degree of atrophy and intestinal metaplasia are correlated (Hum Pathol 2001;32:31)
  • Epithelial changes may become dysplastic and progress to carcinoma
Gross description
  • Thin, smooth mucosa (without rugae), prominent submucosal vessels (due to mucosal atrophy)
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