Diffuse large B cell lymphoma

Topic Completed: 1 September 2012

Minor changes: 14 June 2021

Copyright: 2003-2021,, Inc.

PubMed Search: gastric diffuse large b-cell lymphoma

Elliot Weisenberg, M.D.
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Cite this page: Weisenberg E. Diffuse large B cell lymphoma. website. Accessed September 20th, 2021.
Definition / general
  • High grade B-cell tumor (Am J Surg Pathol 2003;27:790)
  • May arise from transformed extranodal marginal zone (MALT) lymphoma
  • Usually > age 50 years
  • 5 year survival is 65% (related to stage)
  • Coexistence of MALT lymphoma and diffuse large B-cell lymphoma: do not report as "high grade MALT" (MALT is usually indolent); report instead as diffuse large B-cell lymphoma with coexisting MALT lymphoma
Prognostic factors
Case reports
Gross description
  • Large polypoid or lobulated mass with superficial or deep ulceration; often in distal stomach, but sparing pylorus
Microscopic (histologic) description
  • Infiltrative pattern of high grade, centroblast like cells; multinucleated forms may resemble Reed-Sternberg cells
Positive stains
Differential diagnosis
  • Undifferentiated carcinoma: continuity between tumor cells and epithelium, acinar pattern, muscularis mucosa destruction, positive for keratin and mucin
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