Stomach
Lymphoma
Lymphoma-general


Topic Completed: 1 September 2012

Minor changes: 1 September 2020

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PubMed Search: stomach lymphoma

Elliot Weisenberg, M.D.
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Cite this page: Weisenberg E. Lymphoma-general. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stomachlymphomageneral.html. Accessed April 19th, 2021.
Definition / general
  • 55 - 75% of primary gastrointestinal lymphomas are gastric
  • Lymphomas are 1 - 7% of gastric malignancies
  • Diffuse large B-cell lymphoma most common, then extranodal marginal zone (MALT) lymphoma
  • Most patients age 60+
  • Clinically resembles carcinoma, but usually better prognosis
  • Associated with erosion (61%), intestinal metaplasia (59%), H. pylori (57%), atrophy (37%), dysplasia (4%) (Arch Pathol Lab Med 2000;124:1628)
Microscopic (histologic) description
  • Diffuse large B-cell lymphoma generally resembles nodal disease
  • Features highly suggestive of low grade lymphoma versus inflammation are dense lymphoid infiltrates with either prominent lymphoepithelial lesions, moderate cytologic atypia or Dutcher bodies (Am J Surg Pathol 1990;14:1087)
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