Bone
Fibrous and Fibroosseous tumors of bone
Osteofibrous dysplasia


Topic Completed: 1 August 2013

Minor changes: 9 November 2019

Revised: 27 December 2018

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Osteofibrous dysplasia[title]

Nat Pernick, M.D.
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Cite this page: Pernick N Osteofibrous dysplasia. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/boneosteofibrousdysplasia.html. Accessed June 7th, 2020.
Definition / general
  • Non-neoplastic, self-limited intracortical fibroosseous lesion commonly affecting tibia and fibula of children
  • Also called fibroosseous dysplasia, ossifying fibroma of long bones, Campanacci’s lesion
  • Mean age 13 years, range 0-39 years, no gender preference
  • Closely related to fibrous dysplasia but osteofibrous dysplasia is a cortical (not medullary) lesion with osteoblastic rimming of bone and lamellar bone that does mature
  • May present with pathologic fracture
  • Associated with adamantinoma of long bones; may be a precursor lesion (Hum Pathol 2004;35:69, Am J Surg Pathol 1992;16:282)
  • Sites: diaphysis of tibia or fibula of neonates
Radiology images

Contributed by Dr. Mark R. Wick


Radiograph

Prognosis and treatment
  • Excellent, but may recur; regresses as patients mature
Gross images

Contributed by Dr. Mark R. Wick

Focally eroded cortex

Microscopic (histologic) description
  • Spindle cell proliferation with production of woven bone trabeculae with prominent osteoblastic rimming
  • Loose, slightly myxoid stroma
Microscopic (histologic) images

Contributed by Dr. Mark R. Wick

Keratin immunostain


Trabeculae lined by plump osteoblasts

Positive stains
Differential diagnosis
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