Bone
Fibrous and Fibroosseous tumors of bone
Osteofibrous dysplasia

Author: Nat Pernick, M.D. (see Authors page)

Revised: 25 October 2016, last major update August 2013

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed Search: Osteofibrous dysplasia[title]
Cite this page: Osteofibrous dysplasia. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/boneosteofibrousdysplasia.html. Accessed December 4th, 2016.
Definition / General
  • Non-neoplastic, self-limited intracortical fibroosseous lesion commonly affecting tibia and fibula of children
  • Also called fibroosseous dysplasia, ossifying fibroma of long bones, Campanacci’s lesion
  • Mean age 13 years, range 0-39 years, no gender preference
  • Closely related to fibrous dysplasia but is a cortical (not medullary) lesion with osteoblastic rimming of bone and lamellar bone that does mature
  • May present with pathologic fracture
  • Associated with adamantinoma of long bones; may be a precursor lesion (Hum Pathol 2004;35:69, Am J Surg Pathol 1992;16:282)
  • Sites: diaphysis of tibia or fibula of neonates
Radiology Images

Images hosted on Pathout server:

Contributed by Dr. Mark R. Wick

Radiograph

Prognosis and Treatment
  • Excellent, but may recur; regresses as patients mature
Gross Images

Images hosted on Pathout server:

Contributed by Dr. Mark R. Wick

Focally eroded cortex

Micro Description
  • Spindle cell proliferation with production of woven bone trabeculae with prominent osteoblastic rimming
  • Loose, slightly myxoid stroma
Micro Images

Images hosted on Pathout server:

Contributed by Dr. Mark R. Wick

Keratin immunostain - contributed by Dr. Mark R. Wick

Trabeculae lined by plump osteoblasts

Positive Stains
Differential Diagnosis