Table of ContentsDefinition / General | Terminology | Epidemiology | Sites | Clinical Features | Case Reports | Treatment | Micro Description | Micro Images | Positive Stains | Differential Diagnosis
Cite this page: Hepatoid carcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/colontumorhepatoid.html. Accessed February 27th, 2017.
Definition / General
- Rare, aggressive subtype of adenocarcinoma that morphologically resembles hepatocellular carcinoma and produces alpha fetoprotein
- Originally termed "alpha fetoprotein producing tumor"
- More common in men
- Fewer than 20 colonic cases reported
- 42 year old man with rectal hepatoid carcinoma with liver metastases (Hepatobiliary Pancreat Dis Int 2008;7:539)
- 59 year old man with colonic α fetoprotein producing carcinoma (Dis Colon Rectum 2003;46:826)
- 71 year old man with hepatoid carcinoma colliding with liposarcoma (World J Surg Oncol 2007;5:42)
- Rectal tumor arising in ulcerative colitis (Dis Colon Rectum 2000;43:105)
- Sigmoid alpha fetoprotein producing adenocarcinoma (Pathology 1995;27:277)
- Surgery, possibly chemotherapy (Pathol Oncol Res 2012;18:93)
- Resembles hepatocellular carcinoma, with trabecular or solid pattern of large polygonal cells with abundant eosinophilic or clear cytoplasm
- Component of traditional adenocarcinoma also often present
- Lymphovascular invasion is common (Histopathology 1997 Jul;31:47)