Colon tumor
Hepatoid carcinoma

Author: Raul Gonzalez M.D. (see Authors page)

Revised: 2 January 2017, last major update April 2015

Copyright: (c) 2002-2017,, Inc.

PubMed Search: "Hepatoid carcinoma" colon

Cite this page: Hepatoid carcinoma. website. Accessed June 20th, 2018.
Definition / general
  • Rare, aggressive subtype of adenocarcinoma that morphologically resembles hepatocellular carcinoma and produces alpha fetoprotein
  • Originally termed "alpha fetoprotein producing tumor"
  • More common in men
  • Fewer than 20 colonic cases reported
Clinical features
Case reports
Microscopic (histologic) description
  • Resembles hepatocellular carcinoma, with trabecular or solid pattern of large polygonal cells with abundant eosinophilic or clear cytoplasm
  • Component of traditional adenocarcinoma also often present
  • Lymphovascular invasion is common (Histopathology 1997 Jul;31:47)
Microscopic (histologic) images

Images hosted on other servers:

Collision with liposarcoma

Associated with ulcerative colitis

Gastric tumor: H&E, AFP+ Hep Par 1- glypican3+

Differential diagnosis