Prostate
Other carcinomas
Squamous cell carcinoma

Authors: Komal Arora, M.D. (see Authors page)

Revised: 22 August 2016, last major update March 2012

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed search: prostaic squamous cell carcinoma
Definition / General
  • Extremely rare; incidence is < 0.6% of all prostate cancers
  • Criteria for diagnosis of primary squamous cell carcinoma of the prostate:
    • (i) The presence of unequivocal features of malignancy
    • (ii) The presence of definitive squamous differentiation
    • (iii) Lack of a conventional carcinoma component
    • (iv) No prior treatment with radiation or hormones
    • (v) No squamous cell carcinoma elsewhere (Mod Pathol 2004;17:316)
Clinical Features
  • Originates from the periurethral glands or prostatic acinar basal cells
  • Occurs de novo or after estrogen therapy, flutamine therapy, radiation seed implantation
  • Poor survival
  • Have normal serum PSA and PSAP levels
  • Tumors develop osteolytic metastases, don’t respond to hormone therapy
  • Don’t develop increased PSA with metastases
Micro Description
  • Pure tumors exhibit infiltrating nests, strands, and sheets of polygonal cells with nuclear atypia
  • Squamous differentiation is manifested as individual cell keratinization, intercellular bridges or keratin pearl formation
Micro Description
  • Pure tumors exhibit infiltrating nests, strands, and sheets of polygonal cells with nuclear atypia
  • Squamous differentiation is manifested as individual cell keratinization, intercellular bridges or keratin pearl formation
Micro Images

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Negative Stains
  • PSA, PSAP