Prostate - Squamous cell carcinoma

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Prostate

Other carcinomas

Squamous cell carcinoma

Reviewers: Komal Arora, M.D., (see Reviewers page)
Revised: 21 April 2012, last major update March 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Extremely rare; incidence is <0.6% of all prostate cancers
● Criteria for diagnosis of primary squamous cell carcinoma of the prostate:
   ● (i) The presence of unequivocal features of malignancy
   ● (ii) The presence of definitive squamous differentiation
   ● (iii) Lack of a conventional carcinoma component
   ● (iv) No prior treatment with radiation or hormones
   ● (v) No squamous cell carcinoma elsewhere (Mod Pathol 2004;17:316)

Clinical features
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● Originates from the periurethral glands or prostatic acinar basal cells
● Occurs de novo or after estrogen therapy, flutamine therapy, radiation seed implantation
● Poor survival
● Have normal serum PSA and PSAP levels
● Tumors develop osteolytic metastases, don’t respond to hormone therapy
● Don’t develop increased PSA with metastases

Micro description
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● Pure tumors exhibit infiltrating nests, strands, and sheets of polygonal cells with nuclear atypia
● Squamous differentiation is manifested as individual cell keratinization, intercellular bridges or keratin pearl formation

Micro images
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Various images

Negative stains
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● PSA, PSAP

End of Prostate > Other carcinomas > Squamous cell carcinoma

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