Salivary glands
Epithelial / myoepithelial tumors
Large cell neuroendocrine carcinoma

Author: Adriana Handra-Luca, M.D. (see Authors page)

Revised: 14 March 2018, last major update September 2012

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PubMed Search: Large cell neuroendocrine carcinoma salivary

Cite this page: Handra-Luca, A. Large cell neuroendocrine carcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/salivaryglandsLCNC.html. Accessed July 21st, 2018.
Definition / general
  • Extremely rare high grade tumor with neuroendocrine features (organoid, solid, trabecular and rosette-like patterns) and large polygonal cells with coarse chromatin and prominent nucleoli, high mitotic rate, frequent necrosis
  • Less than 20 reported cases - must rule out metastatic disease
Clinical features
  • Usually age 60+ years, affects parotid gland
  • Aggressive behavior
Case reports
Treatment
  • Surgery, radiotherapy
Microscopic (histologic) description
  • Organoid, solid, trabecular and rosette-like patterns of large polygonal cells with coarse chromatin and prominent nucleoli, high mitotic rate, frequent necrosis
Cytology description
  • Resembles undifferentiatiated carcinoma
Negative stains
Molecular / cytogenetics description
  • 9p21 LOH and p16 mutation, TP53 LOH and mutation
Differential diagnosis