Salivary Gland - Necrotizing sialometaplasia

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Salivary glands

Inflammation

Necrotizing sialometaplasia

Reviewers: Fatima Aly, M.D., National Cancer Institute (see Reviewers page)
Revised: 27 February 2012, last major update August 2011
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Reactive, self resolving condition of minor or occasionally major salivary glands, often hard or soft palate, probably due to ischemia or vasculitis

Clinical images
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42 year old woman with bilaterally ulcerated swellings of the palate

Gross description
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● Crater-like ulcerated lesion of hard palate

Micro description
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● Ulcerated surface mucosa
● Intraductal proliferation of metaplastic squamous epithelium containing trapped mucous cells in lobular but noninfiltrative pattern
● Pseudoepitheliomatous hyperplasia common with prominent inflammatory infiltrate and partial necrosis of salivary glands, associated with squamous metaplasia of adjacent ducts and acini

Micro images
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42 year old woman with bilaterally ulcerated swellings of the palate

Differential diagnosis
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● Squamous cell carcinoma, mucoepidermoid carcinoma, post-radiation changes

End of Salivary Glands > Inflammation > Necrotizing sialometaplasia

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