Salivary glands
Inflammation
Necrotizing sialometaplasia


Topic Completed: 1 October 2015

Revised: 20 March 2019

Copyright: 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: Necrotizing sialometaplasia[TI] salivary glands

Sally Tanakchi, M.D.
F. Zahra Aly, M.D., Ph.D.
Page views in 2018: 3,652
Page views in 2019 to date: 3,633
Cite this page: Tanakchi S Necrotizing sialometaplasia. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/salivaryglandsnecrotizingsialo.html. Accessed November 16th, 2019.
Definition / general
  • Reactive, self resolving condition, mostly affecting the palate
  • Heals within 6 - 10 weeks
  • Etiology is thought to be reaction to trauma or smoking in the presence of existing tissue ischemia
  • Mimics malignant diagnosis both clinically and histologically
  • Interestingly, has been reported in the context of bulemia
Case reports
Gross description
  • Crater-like ulcerated lesion of hard palate
Microscopic (histologic) description
  • Pseudoepitheliomatous hyperplasia
  • Squamous metaplasia of ducts and acini
  • Preservation of lobular architecture
  • Lobular infarction with or without mucin spillage
  • Inflammation secondary to extravasation of mucin
  • Conceptualized by 5 stages of development and evolution:
    • Infarction
    • Sequestration
    • Ulceration
    • Repair
    • Healing
Microscopic (histologic) images

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Necrosis and normal gland

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Squamous metaplasia

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Pseudo-epitheliomatous hyperplasia

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Palate biopsy


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NSM versus SCC

Positive stains
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