Stains & CD markers
CD markers - other


Last author update: 13 November 2019
Last staff update: 30 January 2023

Copyright: 2019-2023, PathologyOutlines.com, Inc.

Nat Pernick, M.D.
Page views in 2022: 531
Page views in 2023 to date: 163
Cite this page: Pernick N. CD markers - other. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkersother.html. Accessed February 7th, 2023.
CD150
  • Also known as signal lymphocyte activation molecule (SLAM)
  • Costimulatory molecule on B lymphocytes and dendritic cells
  • Positive staining - normal: thymocytes, CD45RO positive subpopulation of T cells, B cells, dendritic cells, endothelium
CD151
  • May modify integrin function or signaling
  • Positive staining - normal: endothelium, platelets, megakaryocytes, epithelium
CD152
  • Also known as cytotoxic T lymphocyte associated protein 4, CTLA4
  • Negative regulator of T cell activation
  • CTLA4 restriction fragment length polymorphisms are linked to various autoimmune disorders
  • Shares sequence homology with CD28; also shares ligands CD80 and CD86 with CD28
  • Positive staining - normal: activated but not resting T cells, activated B cells
  • Reference: OMIM CD152
CD153
  • Also known as CD30 ligand
  • Enhances CD3 activated T lymphocyte proliferation
CD154
  • Also known as CD40 ligand, CD40L, TNF related activation protein (TRAP)
  • Regulates B cell function by engaging CD40
  • Defective gene prevents immunoglobulin class switch and is associated with hyper IgM syndrome, autoimmune hematologic disorders, disorganized nodal follicular architecture and PAS positive plasmacytoid cells containing IgM, lymph nodes without germinal centers, shortened lifespan, often with gastrointestinal cancers (cholangiocarcinoma, hepatocellular carcinoma and adenocarcinoma) and Cryptosporidium parvum infection
  • Positive staining - normal: T cells
CD155
  • Also known as polio virus receptor
  • Involved in intercellular adhesion
  • Positive staining - normal: embryonic structures giving rise to spinal cord anterior horn motor neurons
CD156a
  • Also known as ADAM8
  • May play a role in muscle differentiation
  • Possible role in neutrophilic extravasation
  • Stains neutrophils, monocytes
CD156b
  • Also known as Tumor necrosis factor Alpha Converting Enzyme (TACE), ADAM17
  • Adhesion structure; releases soluble forms of tumor necrosis factor and transforming growth factor alpha from cells
  • Stains all cells examined, with pro domain removed
CD156c
CD157
  • Also known as Bone marrow STromal cell antigen 1 (BST1)
  • Facilitates pre B cell growth
  • 33% homology to CD38
  • Overexpression may cause polyclonal B cell abnormalities in rheumatoid arthritis
  • Positive staining - normal: granulocytes, monocytes, B cell progenitors, T cell subpopulations
CD158
  • Member of KIR (killer cell immunoglobulin like receptor) family, also called killer cell inhibitory receptors
  • Binding by HLA class I molecules causes inhibition of NK or T cell cytotoxic activity
  • Melanoma specific cytotoxic T lymphocytes may express KIR and regulate their ability to kill these tumors
  • Terminology:
    • CD158c: KIR2DS6 / KIRX
    • CD158d: KIR2DL4
    • CD158e1: KIR3DL1 / p70
    • CD158e2: KIR3DS1 / p70
    • CD158f: KIR2DL5 (Front Immunol 2017;7:698)
    • CD158g: KIR2DS5
    • CD158h: KIR2DS1 / p50.1
    • CD158i: KIR2DS4 / p50.3
    • CD158j: KIR2DS2 / p50.2
    • CD158k: KIR3DL2 / p140
    • CD158z: KIR3DL7 / KIRC1
  • Positive staining - normal: natural killer cells (NK cells), some T cells
CD158a
  • Also known as KIR2DL1 / p58.1
  • Regulates NK cell mediated cytolytic activity
  • Includes 2 different molecules with inhibitory and activation effects, presumably encoded by different genes of the same family
  • Positive staining: NK cell subset
CD158b
  • CD158b1: KIR2DL2 / p58.2
  • CD158b2: KIR2DL3 / p58.3
  • Regulates NK cell mediated cytolytic activity
  • Includes 2 different molecules with inhibitory and activation effects, presumably encoded by different genes of the same family
  • Positive staining: NK cell subset, rare T cells
CD159a
  • Also known as NKG2A, killer cell lectin-like receptor subfamily C member 1
  • Mediates signaling in the killing process by NK cells
  • Positive staining - normal: NK cells
CD159c
  • Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by natural killer cells and some cytotoxic T cells (Front Immunol 2018;9:686)
  • Also known as NKG2C, KLRC2
  • Positive staining - normal: natural killer cells and CD8+ T cells
CD170
  • Aka Sialic acid binding IG-like Lectin 5 (SIGLEC5)
  • May function in cell-cell interaction
  • Positive staining - normal: neutrophils
CD171
  • Aka L1
  • Adhesion molecule required for normal neurohistogenesis
  • Mutations cause CRASH (Corpus callosum hypoplasia / agenesis, Retardation, Aphasia, Spastic paraplegia / shuffling gait and Hydrocephalus due to stenosis of aqueduct of Sylvius), an X linked neurologic disorder
  • May mediate kidney branching morphogenesis, maintenance of lymph node architecture during immune response, costimulation of T cell activation in vitro
  • Positive staining - normal: postmitotic neurons, glia, epithelial cells (some), lymphoid cells (some), myeloid (some), monocytes
CD172a
  • Aka SIRP alpha
  • Adhesion structure
CD173
  • Aka blood group H2
  • Marker of early hematopoiesis
  • Positive staining - normal: CD34+ hematopoietic progenitor cells
  • Negative staining: mature lymphocytes
CD174
  • Aka Lewis Y antigen
  • Marker of early hematopoiesis
  • Positive staining - normal: CD34+ hematopoietic progenitor cells
  • Negative staining: mature lymphocytes
CD175
  • CD175:
    • Aka Tn
    • Simple mucin type carbohydrate antigen produced in the initial steps of mucin biosynthetic pathway, due to aberrant or incomplete glycosylation of mucins
CD176
  • Aka Thomsen-Friedenreich (TF) oncofetal blood group antigen, galactose beta 1-3 N-acetylgalactosamine alpha
  • Occurs in colon cancer and colitis
CD177
  • Aka NB1 glycoprotein
  • Major immunogenic molecule of neutrophil membrane
  • Positive staining - normal: myeloid cells
CD178
  • Aka CD95 ligand, Fas ligand (FasL)
  • Important role in T cell mediated cytotoxicity; induces apoptosis in Fas expressing target cells
  • Cells in immune privileged sites (testis, anterior chamber of eye, placenta) constitutively express FasL, which induces apoptosis in Fas expressing infiltrating T cells, minimizing inflammatory responses that might damage important physiologic functions at these sites
  • May influence interaction of tumor cells with host immune system; theory is that FasL+ tumor cells induce apoptosis in infiltrating Fas+ mononuclear cells
  • Fas-FasL binding triggers apoptosis in lymphocytes
  • Mutations may be related to some cases of Systemic Lupus Erythematosis (SLE)
  • Processed by metalloproteases which cause shedding of extracellular portion into blood (sFas L)
  • Positive staining - normal: activated and cytotoxic T cells, testis, anterior chamber of eye, placenta; also Sertoli cells, neurons, thyroid epithelial cells
  • Positive staining - tumors: Reed-Sternberg cells of Hodgkin’s lymphoma (nodular sclerosis and mixed cellularity) (Am J Surg Pathol 2001;25:388)
CD179
  • CD179a:
    • Aka VpreB1
    • Associates noncovalently with CD179b to form surrogate light chain as component of preB cell receptor, which plays a critical role in early B cell differentiation
  • CD179b:
    • Aka lambda 5
    • Associates noncovalently with CD179a to form surrogate light chain as component of preB cell receptor, which plays a critical role in early B cell differentiation
    • Mutations impair B cell development and cause agammaglobulinemia
  • Positive staining - normal: preB cells
CD180
  • Also called RP105
  • Regulates B cell recognition of lipopolysaccharide, a membrane constituent of gram-negative bacteria
  • Positive staining - normal: mantle zone and marginal zone B cells (strong), other B cells (weak / negative); peripheral blood monocytes, dendritic cells
CD181 / CD128
  • Also called CXCR1, IL8Ralpha; previously called CDw128A
  • Chemokine receptor, powerful neutrophil chemotactic factor
  • Positive staining - normal: neutrophils, basophils, T cell subset, monocytes, keratinocytes
  • Positive staining - disease: T cells in allergic rhinitis (J Immunol 2004;172:268)
CD182 / CXCR2
  • Also called CXCR2; formerly called CD128b
  • Interleukin 8 receptor beta subunit (IL8RB); binds multiple CXC chemokines including IL8 (CXCL8)
  • Chemokine receptor, powerful neutrophil chemotactic factor, particularly to sites of inflammation
  • Interpretation: cytoplasmic staining
  • Uses by pathologists: no significant uses by pathologists
  • Positive staining - normal: mature granulocytes, keratinocytes, neuroendocrine cells, projection neurons (Arch Pathol Lab Med 2000;124:520)
  • Positive staining - disease: carcinoid tumor (classic, atypical, metastatic), pituitary adenoma, pheochromocytoma, medullary carcinoma
  • Negative staining: parathyroid cells; small cell carcinoma of lung / cervix, large cell lung neuroendocrine carcinoma, Merkel cell carcinoma, neuroblastoma, melanoma
  • See Diagrams / tables
  • See Microscopic (histologic) images
CD183 / CXCR3
  • Also called CXCR3
  • Receptor for some chemokines; binding of chemokines to CD183 induces integrin activation, cytoskeletal changes and chemotactic migration in inflammation associated effector T cells
  • CD183+ T cells detected in inflamed tissues of patients with juvenile rheumatoid arthritis, multiple sclerosis, sarcoidosis, hepatitis C
  • Positive staining - normal: T cells in inflamed tissue, eosinophils, plasmacytoid dendritic cells, hematopoietic progenitors
  • Negative staining: naïve T cells in peripheral blood
CD184
  • Also called CXCR4, stromal cell derived factor 1 (SDF1)
  • Receptor for the CXC chemokine SDF1
  • Also major HIV / SIV coreceptor (with CCR5 / CD195)
  • Involved in B cell development, myelopoiesis, cardiac ventricular septum formation, blood vessel formation in GI tract, cerebellar granular cell development
  • Positive staining - normal: all mature blood cells, blood progenitor cells, endothelial and epithelial cells, astrocytes, neurons
CD185
  • Multipass membrane protein of CXC chemokine receptor family
  • Also called CXCR5, BLR1 (Burkitt lymphoma receptor 1)
  • Pathophysiology:
    • Binds to B Lymphocyte Chemoattractant (BLC / CXCL13) (J Exp Med 1998;187:655)
    • Involved in B cell migration into B cell follicles of spleen and Peyer patches (J Immunol 2009;182:2610)
    • Critical for function of follicular helper T (TFH) cells
    • May have role in survival and maintainance of cardiac structure upon pressure overload by regulating proteoglycans essential for correct collagen assembly (PLoS One 2011;6:e18668)
    • May be important for ectopic mucosa associated lymphoid tissue neogenesis in chronic Helicobacter pylori induced inflammation (J Mol Med (Berl) 2010;88:1169)
    • During HIV1 infection, altered expression of CXCR5 / CXCL13 may cause B cell dysfunction (Blood 2008;112:4401)
    • Upregulated in rheumatoid arthritis synovial tissue and expressed in various cell types (Arthritis Res Ther 2005;7:R217)
  • Interpretation: cytoplasmic staining
  • Uses by pathologists: no significant uses by pathologists
  • Positive staining - normal: mature B cells
  • Positive staining - disease: Burkitt's lymphoma, mantle cell lymphoma; AIDS related non-Hodgkin lymphoma (Blood 2009;113:4604, AIDS Res Treat 2010;2010:164586)
  • See Microscopic (histologic) images
CD186
  • No information available
CD187
  • CD Marker not assigned to a set of antibodies as of 20 December 2011
CD188
  • CD Marker not assigned to a set of antibodies as of 20 December 2011
CD189
  • CD Marker not assigned to a set of antibodies as of 20 December 2011
CD190
  • CD Marker not assigned to a set of antibodies as of 20 December 2011
CD191 / CCR1
CD192 / CCR2
  • Receptor for MCP1, MCP3, MCP4 chemokines; alternative coreceptor with CD4 for HIV1
  • Abbreviation for chemokine C-C motif ligand 2 (CCL2) chemokine C-C motif receptor 2
  • Also known as CD192 but most publications use CCR2
  • Inflammatory cytokine with 374 amino acids that mediates biologic effects of CCL2, also known as monocyte chemoattractant protein 1 (MCP1); CCL2-CCR2 may be involved in neuroinflammation and chronic pain (J Neuroinflammation 2012;9:136)
  • During chemotaxis, may act as scavenger consuming the chemokine (PLoS One 2012;7:e37208)
  • Clinical features:
  • Uses by pathologists: none
  • Positive staining: neurons, monocytes; controversial if expressed on microglia or due to infiltrating monocytes
  • See Diagrams / tables
CD193 / CCR3
CD194 / CCR4
CD195 / CCR5
CD196 / CCR6
CD197 / CCR7
CD198 / CCR8
CD199 / CCR9
CDw210
  • Aka IL10 receptor
  • Interleukin 10 produced by B cells, T helper cells and monocyte / macrophages, exhibits diverse activities on different cell lines (OMIM 124092)
  • IL10 inhibits macrophage activation by interferon gamma
  • Positive staining - normal: monocytes, B and T cells, large granular lymphocytes, spleen, thymus, placenta, lung, liver
CD211
  • CD Marker not assigned to a set of antibodies as of 20 December 2011
CD212
  • Aka IL12 receptor
  • Interleukin 12 promotes cell mediated immunity to intracellular pathogens by inducing type 1 helper T cell responses and interferon gamma production
  • Lack of IL12 associated with severe, idiopathic mycobacterial and Salmonella infections, mature granulomas
  • Positive staining - normal: T cells, NK cells
CD213
  • CD213a1:
    • Aka IL13 receptor, alpha 1
    • Binds IL13 with low affinity
    • With IL4r-alpha, can form a functional receptor for IL13
    • Positive staining - normal: ubiquitous, B cells, T cells and endothelial cells, highest levels in heart, liver, skeletal muscle and ovary
  • CD213a2:
    • Aka IL13 receptor, alpha 2
    • Inhibits binding of interleukin 13 to the IL13 cell surface receptor
    • Positive staining - normal: placenta
CD214
  • No information available
CD215
  • CD Marker not assigned to a set of antibodies as of 20 December 2011
CD216
  • CD Marker not assigned to a set of antibodies as of 20 December 2011
CDw217
  • Aka IL 17 receptor
  • Cytokine that is induced in activated CD4+ T cells
  • IL17 induces stromal cells to produce proinflammatory and hematopoietic cytokines; enhances expression in fibroblasts of ICAM1
CD218
  • No information available
CD219
  • CD Marker not assigned to a set of antibodies as of 20 December 2011
CD220
  • Aka insulin receptor
CD221
  • Aka insulin-like growth factor 1 receptor
  • Mediates insulin stimulated DNA synthesis and IGF1 stimulated cell proliferation and differentiation
  • Often overexpressed in malignant tissue, where it functions as an anti-apoptotic agent by enhancing cell survival
CD222
  • Aka insulin-like growth factor 2 receptor, mannose 6 phosphate receptor
  • Also a receptor for lysosomal hydrolases (i.e. assists in sorting lysosomal enzymes from Golgi apparatus or extracellular space to lysosomes)
CD223
  • Aka Lymphocyte-Activation Gene 3 (LAG3)
  • Homologous to CD4
  • Associates with MHC class II molecules on monocytes/dendritic cells, which are subsequently activated
  • May help activated CD4+ and CD8+ T cells to fully activate monocytes and dendritic cells, leading to optimized MHC class I and class II T cell responses
  • Positive staining - normal: activated T cells, activated NK cells
CD224
  • Aka gamma-glutamyltransferase
  • Gene at 22q11.1-q11.2
  • Catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors, which maintains a homeostatic balance regarding oxidative stress
CD225
  • Aka Leu13, interferon-inducible transmembrane protein 1
  • Involved in relaying antiproliferative and homotypic adhesion signals
CD226
  • Aka DNAM1, Platelet and T cell Activation antigen 1 (PTA1)
  • Mediates adhesion to an unknown ligand
  • T cell expression increased in some patients with autoimmune disease and viral infection
  • Positive staining - normal: NK cells, platelets, monocytes, subset of B and T cells
  • Negative staining: granulocytes, erythrocytes
CD227
CD228
  • Aka melanotransferrin
  • Cell surface glycoprotein found on melanoma cells, with sequence similarity and iron binding properties of transferrin superfamily
CD229
  • Aka lymphocyte antigen 9
  • May be involved in adhesion between T cells and accessory cells
CD240CE
  • Also called RH 30 CE, Rh blood group Cc and Ee blood group antigens; encodes RhC and RhE antigens on a single polypeptide
  • On #1p36.11 adjacent to RH D gene
  • Rh (rhesus) blood group system is second most clinically significant blood group after ABO; is most polymorphic blood group, with variations due to deletions, gene conversions and missense mutations
  • Rh antigens are carried by an oligomer of two major erythroid specific polypeptides, the Rh (D and CcEe) proteins and the RhAG glycoprotein
  • Discrepant or doubtful serologic results can be resolved by sequence specific primer (PCR SSP) technique (Transfusion 2007;47:54S)
  • Rarely causes hemolytic disease of newborn (Transfus Med 2000;10:305)
  • Uses by pathologists: blood typing
  • Positive staining - normal: erythroid cells
  • References: Blood 2000;95:375, OMIM 111700
CD240D
  • Also called RH30 D, Rh blood group D blood group antigen; is major antigen of the Rh system
  • On #1p36.11 adjacent to RHCE gene
  • Rh (rhesus) blood group system is second most clinically significant blood group after ABO; is most polymorphic blood group, with variations due to deletions, gene conversions and missense mutations
  • Weak D, formerly called D(u), occurs in 0.2 to 1% of whites
  • Individuals are classified as Rh positive or negative based on presence or absence of highly immunogenic D antigen on red cell surface
  • May have arisen historically by duplication of RHCE gene (Blood 2002;99:2272)
  • Discrepant or doubtful serologic results can be resolved by sequence specific primer (PCR SSP) technique (Transfusion 2007;47:54S)
  • Hemolytic disease of fetus and newborn: usually due to Rh negative woman whose partner is Rh+ or heterozygous and fetus is Rh+; woman has preexisting anti-RhD antibodies that cross placenta and harm fetus (Immunohematol 2006;22:188)
  • Can use maternal plasma in alloimmunized pregnancies to determine fetal RhD status or for RHD and RHCE genotyping (Fetal Diagn Ther 2006;21:404, Prenat Diagn 2005;25:1079)
  • Rh positive mothers may rarely (0.15%) develop new antibodies (other than anti-RHD) in third trimester but no clinical significance (J Matern Fetal Neonatal Med 2007;20:59)
  • Having Rh negative mother may be risk factor for autistic children, due to use of mercury containing Rho-immune globulin (J Matern Fetal Neonatal Med 2007;20:385)
  • Uses by pathologists: blood typing
  • Positive staining - normal: erythroid cells
  • References: OMIM 111680, Wikipedia, eMedicine (Rh incompatibility)
CD240DCE
  • Rh30D / CE crossreactive monoclonal antibodies
  • Uses by pathologists: blood typing
  • Positive staining - normal: erythroid cells of normal Rh types
  • Negative staining: Rh null erythrocytes
CD241
CD242
  • Also called intercellular adhesion molecule 4 (ICAM4), Landsteiner-Wiener (LW) blood group protein
  • Discovered with antibody raised in guinea pigs injected with the cells of rhesus monkeys but Rh designation had already been taken
  • Binds to CD11a / CD18, CD11b / CD18 and CD11c / CD18 (Blood 2007;109:802)
  • May be critical in erythroblastic island formation, where erythroid progenitors differentiate (Blood 2006;108:2064)
  • May be ligand for platelet activated alpha IIb beta 3 integrin (J Biol Chem 2003;278:4892)
  • In sickle cell disease, contributes to red cell endothelial cell adhesion and vasoocclusion (Transfus Clin Biol 2006;13:44)
  • Uses by pathologists: no significant clinical use by pathologists
  • Positive staining - normal: erythroid cells
  • References: OMIM 111250
CD243
CD244
CD245
  • Also called p220 / 240
  • Very little information is available for CD245 directly; appears to be identical to NPAT (nuclear protein, ataxia-telangiectasia locus)
  • NPAT links S phase cyclin E / Cdk2 kinase activity to replication dependent histone gene transcription (Biochemistry 2006;45:15915, Mol Cell Biol 2005;25:6140)
  • Uses by pathologists: no significant clinical use by pathologists
  • Positive staining - normal: T cells (some), other white blood cells with varying intensity
CD246
CD247
CD248
CD249
CD281
  • TLR1_HUMAN (Q15399, OMIM 601194)
  • TLR1, toll-like receptor 1 (toll / interleukin 1 receptor-like) (TIL)
CD282
  • TLR2_HUMAN (O60603, OMIM 603028)
  • TLR2, TIL4, toll-like receptor 2 (toll / interleukin 1 receptor-like protein 4)
CD283
CD284
CD289
CD303
  • No information at this time
CD333
CD351
CD352
  • First described as CD352 at HLDA9 in 2011 (Immunol Lett 2011;134:104)
  • Also known as Signaling lymphocytic activation molecule F6 (SLAMF6), Ly108 and NTBA
  • Member of SLAM (CD150) family of receptors, which are leukocyte cell-surface glycoproteins involved in leukocyte activation; these molecules and their adaptor protein SAP contribute to germinal center formation, generation of plasma cells and memory B cells (Immunol Lett 2011;134:129)
  • Costimulatory molecule with CD28 implicated in formation of Th17 lymphocytes and IL17A expression (J Biol Chem 2012;287:38168)
  • One of several risk loci for Graves disease of thyroid (Hum Mol Genet 2013;22:3347)
  • Increased expression on surface of T cells in system lupus erythematosus (J Immunol 2012;188:1206); this pathway may be defective in SLE T cells (Autoimmunity 2011;44:211)
  • No usage for pathologists at this time
  • Positive staining (normal): B cells, plasma cells (Immunol Lett 2011;134:122); also NK, T cells (Wikipedia)
CD353
CD354
  • Triggering REceptor on Myeloid cells; member of Ig superfamily
  • sTREM1: soluble levels of TREM1
  • Part of family of immune sensors which signal innate immune system and amplifies immune responses that promote pro-inflammatory cytokine production; neutrophils are major source of TREM1
  • TREM1 is an activating receptor and requires association with transmembrane adapter molecule DAP12 (DNAX-associated protein 12) for cell signaling (PLoS One 2013;8:e82498, J Leukoc Biol 2013;93:209)
  • TREM1 and MMPs orchestrate an "adaptive" form of innate immunity by modulating the monocyte response to endotoxin (J Leukoc Biol 2012;91:933)
  • Dendritic cells: TREM1 induction by hypoxic microenvironment activates immature dendritic cells and regulates Th1 cell trafficking (Eur J Immunol 2013;43:949)
  • Positive staining: Myeloid cells

Clinical featuresUses by pathologists
  • Differentiate bacterial versus nonbacterial infections (PLoS One 2013;8:e65436)
  • Early diagnosis of sepsis (BMC Infect Dis 2012;12:157)
  • CD355
    • Class I MHC Restricted T cell Associated Molecule
    • First identified at 9th Human Leukocyte Differentiation Antigens Workshop in 2011 / HLDA9 (Immunol Lett 2011;134:104)
    • Expressed in epithelial cells along lateral membrane; important for early cell-cell contacts and cell-substrate interactions (J Cell Biochem 2010;111:111)
    • Binds to cell adhesion molecule nectin-like 2 (Necl2) (Structure 2013;21:1430)
    • Rapidly induced in NK, NKT and CD8+ T cells (Mol Immunol 2009;46:3379); may promote cytotoxic function of NK cells and lead to IFN-γ secretion by CD8+ T cells through interaction with Necl2 (J Immunol 2013;190:4868, Curr Opin Immunol 2012;24:246)
    • 3 common variants of CRTAM gene are associated with an increased rate of asthma exacerbations based on a low circulating vitamin D level (J Allergy Clin Immunol 2012;129:368)
    • No uses by pathologists at this time
    • Positive staining: Epithelial cells; activated CD8+ and natural killer T cells
    CD357
    CD358
    CD360
    CD361
    CD365
    CD366
    CD367
    CD368
    CD369
    CD370
    CD371
  • CLEC12A is a type II transmembrane protein easily detectable by flow cytometry (Clin Transl Immunology 2016;5:e57)
  • Identifies most DUX4+ B ALL cases (Haematologica 2019;104:e352)
  • May be useful in identifying residual disease in AML (Blood Rev 2019;34:26)
  • Has important role in recognizing dead cells, plasmodium derived hemozoin and cerebral malaria development (Cell Rep 2019;28:30)
  • Positive staining (normal): innate immune cells (granulocytes, macrophages and dendritic cells); basophils (Cytometry B Clin Cytom 2018;94:520)
  • Positive staining (disease): acute myeloid leukemia cells (Clin Transl Immunology 2016;5:e57)
  • Diagrams / tables

    Images hosted on other servers:

    CD182: inflammatory infiltration

    CCR2: lamina propria lymphocytes

    CCR5: HIV entry into CD4+ cell via CCR5 coreceptor

    CCR6: immature
    dendritic cells
    traffic to lung via
    CCR6 / CCL20 axis

    Missing Image

    CD247: T cell activation

    Microscopic (histologic) images

    Images hosted on other servers:

    CD182: ovarian carcinoma

    CD185: chronic H. pylori gastris (left); MALT lymphoma (right)

    CD185: AIDS related non-Hodgkin lymphoma

    CD185: synovium of nonrheumatoid arthritis (left) and rheumatoid arthritis (right)


    Missing Image

    CCR2: human glomeruli

    Missing Image

    CCR3: eosinophils and airway epithelium

    Missing Image

    CCR3: lymph nodes involved by Hodgkin disease

    Missing Image

    CCR3: cutaneous T cell lymphoma

    Missing Image

    CCR3: paraffin embedded malignant melanoma

    Missing Image

    CCR3: renal cell carcinoma


    Missing Image

    CCR4: lymph node normal

    Missing Image Missing Image Missing Image Missing Image

    CCR4: lymph node and peripheral blood (adult T cell leukemia / lymphoma)

    Missing Image

    CCR4: Sézary syndrome


    Missing Image

    CCR6: nonsmall cell lung carcinoma

    Missing Image

    CCR6: lung sarcoidosis

    Missing Image

    CCR6: lymph node melanoma

    Missing Image

    CCR6: memory T cells in the spleen

    Missing Image

    CCR6: inflamed tonsils


    Missing Image

    CCR7: various breast carcinomas

    Missing Image

    CCR7: T cells in advanced adenocarcinoma in colorectum

    Missing Image

    CCR7: esophageal SCC and metastatic lymph node

    Missing Image

    CCR7: lymphoma T cells

    Missing Image

    CCR7: skin melanoma and sentinel lymph node


    Missing Image

    CCR9: normal and carcinoma ovaries

    Missing Image

    CD247: normal expression

    Missing Image

    CD247: reduced expression

    Missing Image

    CD248: IHC detection of FB5 antigen

    Virtual slides

    Images hosted on other servers:

    Cerebellum

    Tonsil

    Lymph node

    Pancreas

    Cerebral cortex

    Spleen


    Ovarian stroma cells

    Bone marrow

    Parathyroid

    Prostate

    Pancreatic cancer

    Back to top
    Image 01 Image 02