Lymph nodes & spleen, nonlymphoma

Lymph nodes-vascular lesions

Angiomyomatous hamartoma

Last author update: 1 January 2014
Last staff update: 2 February 2024 (update in progress)

Copyright: 2003-2024,, Inc.

PubMed Search: Angiomyomatous hamartoma

Patricia Tsang, M.D., M.B.A.
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Cite this page: Tsang P. Angiomyomatous hamartoma. website. Accessed February 22nd, 2024.
Definition / general
  • First described by Chan et al. in 1992 (Am J Surg Pathol 1992;16:335)
  • Rare and benign vascular disorder due to proliferation of blood vessels and smooth muscle in lymph nodes, often of long duration
  • Unknown etiology; may represent reparative reaction to previous nodal inflammation
Clinical features
  • Usually males, all ages
  • Benign clinical course
  • Local excision is curative
  • No known recurrence or metastasis
Case reports
Gross description
  • Enlarged and matted lymph nodes replaced by firm, white tissue
Gross images

AFIP images

Replacement by tan, firm tissue

Microscopic (histologic) description
  • Extensive and multifocal nodal involvement by thick walled hilar blood vessels, often with increased fibrous tissue
  • Nodal parenchyma has haphazard smooth muscle cells in sclerotic stroma
  • Starts in nodal hilum and extends toward cortex
  • May have admixed adipose tissue
  • No cellular pleomorphism, no necrosis, low mitotic rate
Microscopic (histologic) images

AFIP images

Angiomyomatous hamartoma of lymph node

Case #118



Immunohistochemistry & special stains
Differential diagnosis
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