Mandible & maxilla
Giant cell lesions & nonepithelial bone cysts
Central giant cell granuloma
Author: Nat Pernick, M.D.
Last author update: 1 October 2013
Last staff update: 1 March 2021
Copyright: 2004-2023, PathologyOutlines.com, Inc.
PubMed Search: Central giant cell granuloma [title]
Table of Contents
Definition / general | Radiology description | Treatment | Gross description | Microscopic (histologic) description | Microscopic (histologic) images | Positive stains | Electron microscopy description | Differential diagnosisCite this page: Pernick N. Central giant cell granuloma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/mandiblemaxillacentralgiantcellgranuloma.html. Accessed March 21st, 2023.
Definition / general
- Also called giant cell reparative granuloma
- Central if intraosseous; peripheral if extraosseous
- May be due to recurrent slow, minute hemorrhages
- Often associated with trauma
- Children and young adults, usually females
- Lesion appears to be unique to jaw
- Usually anterior mandible
Radiology description
- Radiolucent, multilocular lesion, may have resorption / movement of teeth and penetration of jaw cortex
Treatment
- Excision, thorough curettage
- May recur
Gross description
- Cystic bone lesion
Microscopic (histologic) description
- Numerous osteoclast-like giant cells near hemorrhagic areas, cellular vascular and fibrous stroma, new bone formation at edge of lesion
- Frequent mitotic figures
- No necrosis
Microscopic (histologic) images
Contributed by Kelly Magliocca, D.D.S., M.P.H.
Central giant cell granuloma
Positive stains
- CD68 (giant cells)
Electron microscopy description
- Fibroblasts, myofibroblasts, histiocytes
Differential diagnosis
