Salivary glands

Primary salivary gland neoplasms



Topic Completed: 1 September 2012

Minor changes: 13 January 2021

Copyright: 2003-2021,, Inc.

PubMed Search: Sialoblastoma salivary glands

Adriana Handra-Luca, M.D., Ph.D.
Page views in 2020: 1,348
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Cite this page: Handra-Luca A. Sialoblastoma. website. Accessed December 4th, 2021.
Definition / general
Clinical features
  • Childhood epithelial salivary gland tumor; common among the perinatal tumors
  • Occurs in submandibular, parotid or minor salivary glands; also ectopic salivary gland tissue
  • Uni or multinodular, 2 - 7 cm, rapid growth
  • May recur locally or involve regional lymph nodes; also lung metastases
Case reports
Microscopic (histologic) description
  • Ductules and solid organoid nests of basaloid cells with fine chromatin and cuboidal epithelial cells
  • 2 histological patterns: favorable pattern with semiencapsulation of benign basaloid cells with intervening stroma; unfavorable pattern with anaplastic basaloid cells, broad pushing to infiltrative periphery and minimal stroma (Ann Diagn Pathol 2006;10:320)
  • Variable necrosis, variable mitotic activity, variable nuclear atypia, no perineurial invasion
Microscopic (histologic) images

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One year old boy with parotid tumor

Recurrent and metastatic tumor

Nests of basaloid cells

Cytology description
  • Tight, solid clusters of atypical basaloid cells plus dispersed epithelial and myoepithelial cells with metachromatic magenta hyaline globular material
Positive stains
Differential diagnosis
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