Skin melanocytic tumor

Deep penetrating, BAP1 inactivated & pigmented epithelioid melanocytomas

Deep penetrating nevus

Topic Completed: 1 June 2014

Minor changes: 15 January 2021

Copyright: 2003-2021,, Inc.

PubMed Search: deep penetrating nevus [title]

Christopher S. Hale, M.D.
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Cite this page: Hale CS. Deep penetrating nevus. website. Accessed November 27th, 2021.
Definition / general
  • Very cellular melanocytic nevus consisting of spindled melanocytes extending into reticular dermis or subcutis (Arch Dermatol 1993;129:328)
Clinical features
Case reports
Clinical images

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Linear distribution of nevi behind ear

Microscopic (histologic) description
  • Nevus whose dermal component extends into reticular dermis or subcutis
  • Cellular, nested or fascicular with abundant pigment and mild atypia
  • Usually inconspicuous junctional component
  • Plump regular nests of melanocytes in dermis
  • Mild cytologic atypia with some nuclear pleomorphism, small to medium-sized eosinophilic nucleolus (Arch Pathol Lab Med 2011;135:321)
  • Occasional normal dermal mitotic figures, patchy mononuclear inflammatory cell infiltrate
  • Absence of maturation
  • May be combined with other nevi
Microscopic (histologic) images

Contributed by Mark R. Wick, M.D.
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Breast skin

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Various images

Differential diagnosis
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