Soft tissue

Extraskeletal bone tumors

Soft tissue chondroma



Last author update: 6 November 2023
Last staff update: 17 November 2023

Copyright: 2002-2024, PathologyOutlines.com, Inc.

PubMed Search: Soft tissue chondroma

Fireneh N. Beshah, M.D.
Jaylou M. Velez-Torres, M.D.
Page views in 2023: 12,090
Page views in 2024 to date: 2,542
Cite this page: Beshah FN, Velez Torres JM. Soft tissue chondroma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/softtissueeskchondroma.html. Accessed February 23rd, 2024.
Definition / general
  • Benign, cartilage forming tumor that usually arises in the vicinity of joints or tendons in the hands and feet of adults
Essential features
  • Arises from soft tissue of fingers, hands and feet
  • Not connected to the underlying bone
  • Well circumscribed, cartilaginous proliferation
Terminology
  • Soft tissue chondroma, extraskeletal chondroma, chondroma of soft parts
ICD coding
  • ICD-10: D21.9 - benign neoplasm of connective and other soft tissue, unspecified
Epidemiology
Sites
  • Mostly occurs in the fingers
  • Hands, toes, feet and trunk are less frequently affected
Clinical features
  • Occurs in soft tissue of hands and feet
  • Solitary, slowly enlarging nodule; occasionally causes pain or tenderness
  • Reference: Histopathology 1986;10:147
Diagnosis
  • Clinical presentation
    • Solitary nodule
    • Involves fingers, toes and hands
    • < 3 cm
  • Imaging
    • Computed tomography
    • Magnetic resonance imaging
  • Reference: Histopathology 1986;10:147
Radiology description
  • Well demarcated
  • Does not involve bone, although some tumors cause compression deformities or bone erosion
  • Discrete, irregular, ring-like or curvilinear calcifications
  • Reference: AJR Am J Roentgenol 1985;144:1263
Radiology images

Contributed by Andrew E. Rosenberg, M.D.
Calcified lesion

Calcified lesion

Well circumscribed, calcified soft tissue mass

Well circumscribed, calcified soft tissue mass

Prognostic factors
Case reports
Treatment
  • Simple excision
Clinical images

Contributed by Andrew E. Rosenberg, M.D.
Swelling over the toe

Swelling over the toe



Images hosted on other servers:
Foot tumor

Foot tumor

Gross description
  • Well demarcated, oval - round
  • < 3 cm in size
Gross images

Images hosted on other servers:
Well circumscribed mass

Well circumscribed mass

Foot tumor Foot tumor

Foot tumor

Frozen section description
Frozen section images

Contributed by Fireneh N. Beshah, M.D. and Jaylou M. Velez Torres, M.D.
Hypocellular cartilage

Hypocellular cartilage

Chondrocytes with small nuclei

Chondrocytes with small nuclei

Microscopic (histologic) description
  • Mature hyaline cartilage arranged in lobules with sharp borders
  • Chondrocytes in lacunae, arranged diffusely or in small clusters
  • Rarely can have moderate pleomorphism
  • 33% show focal or diffuse calcifications
  • Chondroblastoma-like soft tissue chondroma shows hypercellular areas with cells resembling chondroblasts, recently reclassified as calcified chondroid mesenchymal tumor (Mod Pathol 2021;34:1373)
Microscopic (histologic) images

Contributed by Andrew E. Rosenberg, M.D.
Well circumscribed nodule

Well circumscribed nodule

Peripheral ossification

Peripheral ossification

Enlarged nuclei

Enlarged nuclei

Fibrous pseudocapsule

Fibrous pseudocapsule

Cellular and myxoid areas

Cellular and myxoid areas

Fibrocartilage

Fibrocartilage

Cytology images

Images hosted on other servers:
Foot tumor

Foot tumor

Positive stains
Negative stains
Molecular / cytogenetics description
Sample pathology report
  • Right hip mass, excision:
    • Soft tissue chondroma
Differential diagnosis
  • Synovial chondromatosis:
    • Large joints, multiple small nodules attached to synovial membrane
    • Cloning / clustering of chondrocytes
    • FN1 gene rearrangement (Mod Pathol 2019;32:1762)
    • The mutual exclusivity of ACVR2A rearrangements observed in synovial chondromatosis and FGFR1 / 2 in soft tissue chondromas suggests these represent separate entities (Mod Pathol 2019;32:1762)
  • Calcifying aponeurotic fibroma:
    • Islands of calcification surrounded by palisaded epithelioid fibroblasts (resembling chondrocytes), poorly circumscribed and infiltrative
  • Juxtacortical chondroma:
    • Attached to surface of bone
  • Acral fibrochondromyxoid tumor:
  • Calcified chondroid mesenchymal tumor:
    • Multinodular architecture with increased cellularity towards the periphery of the nodules (Mod Pathol 2021;34:1373)
    • Matrix frequently shows coarse, grungy to lacy calcifications, which are refractive rhomboid crystals under polarized light
    • Osteoclast-like giant cells are frequently identified
Board review style question #1

A 42 year old man presented with a painless soft tissue nodule on the right index finger. Magnetic resonance imaging showed a 2 cm well circumscribed nodule (T1 hypointense) with no connection to the underlying bone. What is the diagnosis?

  1. Chondrosarcoma
  2. Osteochondroma
  3. Soft tissue chondroma
  4. Synovial chondromatosis
Board review style answer #1
C. Soft tissue chondroma. The histology shows a nodule of cartilage surrounded by fibrous tissue, which is characteristic of soft tissue chondroma. Answer D is incorrect because synovial chondromatosis is characterized by multinodular mass with superficial synovial lining. Answer A is incorrect because chondrosarcomas tend to be hypercellular and have cytologic atypia. Answer B is incorrect because the tumor is not connected to the underlying bone and does not have the characteristic trabecular bone with cartilage cap.

Comment Here

Reference: Soft tissue chondroma
Board review style question #2
Which of the following is a feature of soft tissue chondroma?

  1. Arises from big joints like hip and knee joint
  2. Size is usually > 3 cm
  3. Tends to be a solitary nodule
  4. Usually arises from the underlying bones
Board review style answer #2
C. Tends to be a solitary nodule. Soft tissue chondroma usually presents as a single nodule. Answer B is incorrect because soft tissue chondromas are < 3 cm in size in the majority of cases. Answer D is incorrect because soft tissue chondromas have no connection to the underlying bone. Answer A is incorrect because soft tissue chondromas usually involve fingers, toes and hands.

Comment Here

Reference: Soft tissue chondroma
Back to top
Image 01 Image 02