Testis & epididymis

Nonneoplastic lesions


Topic Completed: 1 August 2012

Minor changes: 10 September 2020

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PubMed Search: Testis and epididymis Atrophy

Turki Al-Hussain, M.D.
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Cite this page: Al-Hussain T. Atrophy. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/testisatrophy.html. Accessed October 15th, 2021.
  • Testicular regression syndrome:
    • Affects 5% with cryptorchidism (Arch Pathol Lab Med 2000;124:694)
    • Testicular tissue is replaced by fibrovascular nodule (mean 1.1 cm), calcification, hemosiderin
    • Patient has only rudimentary epididymis and spermatic cord with vas deferens
    • Possibly due to testicular infarct (Histopathology 1991;19:269)
  • Post vasectomy: thickening of tubular wall, reduced spermatids, reduced Sertoli cells, variable interstitial fibrosis
  • AIDS (Am J Clin Pathol 1990;93:196), atherosclerosis (Arch Pathol Lab Med 1985;109:663), cachexia, chemotherapy (cyclophosphamide), cryptorchidism, dibromochloropropane (for nematodes), exhaustion after persistent FSH stimulation, female sex hormones, hepatic cirrhosis (causes elevated serum estrogen), hypopituitarism, Klinefelter syndrome, mumps or other inflammatory orchitis (particularly if postpubertal), radiation, semen outflow obstruction, testicular regression syndrome, vasectomy
Gross images

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Comparison to normal testis

Microscopic (histologic) description
  • Small tubules, thick basement membranes, few or no germ cells
  • Interstitial fibrosis, often increased Leydig cells
Microscopic (histologic) images

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Focal atrophy of tubules

Atrophic testis

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