Testis & paratestis

Germ cell tumors

Regressed germ cell tumor

Editorial Board Member: Maria Tretiakova, M.D., Ph.D.
Mit D. Shah, B.S.
Debra L. Zynger, M.D.

Last author update: 25 March 2022
Last staff update: 4 August 2023

Copyright: 2018-2023, PathologyOutlines.com, Inc.

PubMed Search: Regressed germ cell tumor testicular

Mit D. Shah, B.S.
Debra L. Zynger, M.D.
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Cite this page: Shah MD, Zynger D. Regressed germ cell tumor. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/testisregressedgct.html. Accessed September 25th, 2023.
Definition / general
Essential features
  • Regressed germ cell tumor
  • Burned out germ cell tumor
  • Burnt out germ cell tumor
Clinical features
Radiology description
Radiology images

Images hosted on other servers:

Scrotal ultrasound

primary with

Prognostic factors
  • Posttreatment disease free survival rate: 29% at 5 years and 12% at 10 years (J Urol 2009;182:2303)
  • No difference in prognosis between complete and partial regression (J Urol 2009;182:2303)
  • In context of regressed germ cell tumor with metastasis, pure seminoma has a more favorable prognosis (J Urol 2009;182:2303)
  • No data is available comparing prognosis of regressed versus nonregressed testicular germ cell tumors
Case reports
Gross description
Gross images

Contributed by Debra L. Zynger, M.D.

Complete regression (pT0)

Germ cell neoplasia in situ only (pTis)

Partial regression (pT1)

Microscopic (histologic) description
Microscopic (histologic) images

Contributed by Debra L. Zynger, M.D.


Acellular matrix

Small vessels


Germ cell neoplasia in situ

OCT3 / 4



Molecular / cytogenetics description
  • Identification of isochromosome 12p by FISH can confirm a testicular germ cell tumor metastasis although immunohistochemistry is more commonly used and has wider availability
Sample pathology report
  • Left testicle and spermatic cord, radical inguinal orchiectomy:
    • Scar (1.5 cm) and germ cell neoplasia in situ, consistent with regressed germ cell tumor (see synoptic report, pTis NX)
    • Comment: the germ cell neoplasia in situ expresses OCT3/4, D2-40, CD117 and PLAP
Differential diagnosis
Board review style question #1

Germ cell neoplasia in situ is found adjacent to a scar, consistent with regressed germ cell tumor. Positive expression using which of the following can confirm the germ cell neoplasia in situ?

  1. AFP
  2. Beta hCG
  3. CD30
  4. CK7
  5. OCT3 / 4
Board review style answer #1
Board review style question #2
What is the most common tumor subtype in a partially regressed testicular germ cell tumor?

  1. Choriocarcinoma
  2. Embryonal carcinoma
  3. Seminoma
  4. Teratoma
  5. Yolk sac tumor
Board review style answer #2
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