Large cell neuroendocrine carcinoma

Topic Completed: 1 May 2007

Revised: 28 December 2018, last major update May 2007

Copyright: (c) 2007-2017, PathologyOutlines.com, Inc.

PubMed Search: large cell neuroendocrine carcinoma [title] cervix

Branko Perunovic D.M.
Page views in 2018: 1,021
Page views in 2019 to date: 738
Cite this page: Perunovic B. Large cell neuroendocrine carcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cervixlargecellneuroendocrine.html. Accessed August 21st, 2019.
Definition / general
  • Rare ( < 1% of cervical carcinomas)
  • Mean age 34 years, range 21 to 62 years
  • Presents with abnormal Pap smear or vaginal bleeding
  • Aggressive behavior, similar to lung counterpart, with early metastases to regional lymph nodes and liver, lung, bone and brain (Int J Gynecol Pathol 2003;22:226)
  • Median survival < 2 years
Case reports
Microscopic (histologic) description
  • Defined as moderate to severe nuclear atypia, neuroendocrine differentiation with cells larger than typical small cell carcinoma
  • Insular, trabecular, glandular and solid growth patterns
  • Usually eosinophilic cytoplasmic granules, > 10 MF/10 HPF and extensive necrosis
  • Angiolymphatic invasion
  • Often with adjacent adenocarcinoma in situ
Microscopic (histologic) images

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Case of the Week #327:






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Trabecular pattern with mitotic activity

With adenocarcinoma in situ

Metastatic to bone marrow

Keratin+ (MNF116)
in paranuclear
dot-like pattern


Negative stains
Molecular / cytogenetics description
Electron microscopy images

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Differential diagnosis
Additional references
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