Other epithelial tumors

Large cell neuroendocrine carcinoma

Last author update: 1 May 2007
Last staff update: 17 May 2021

Copyright: 2007-2023, PathologyOutlines.com, Inc.

PubMed Search: large cell neuroendocrine carcinoma [title] cervix

Branko Perunovic, D.M.
Page views in 2022: 1,891
Page views in 2023 to date: 787
Cite this page: Perunovic B. Large cell neuroendocrine carcinoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cervixlargecellneuroendocrine.html. Accessed May 31st, 2023.
Definition / general
  • Rare ( < 1% of cervical carcinomas)
  • Mean age 34 years, range 21 to 62 years
  • Presents with abnormal Pap smear or vaginal bleeding
  • Aggressive behavior, similar to lung counterpart, with early metastases to regional lymph nodes and liver, lung, bone and brain (Int J Gynecol Pathol 2003;22:226)
  • Median survival < 2 years
Case reports
Microscopic (histologic) description
  • Defined as moderate to severe nuclear atypia, neuroendocrine differentiation with cells larger than typical small cell carcinoma
  • Insular, trabecular, glandular and solid growth patterns
  • Usually eosinophilic cytoplasmic granules, > 10 MF/10 HPF and extensive necrosis
  • Angiolymphatic invasion
  • Often with adjacent adenocarcinoma in situ
Microscopic (histologic) images

Case #327
Missing Image Missing Image Missing Image


Missing Image


Missing Image


Missing Image


Missing Image


Positive stains
Negative stains
Molecular / cytogenetics description
Electron microscopy images

Images hosted on other servers:
Missing Image


Differential diagnosis
Additional references
Back to top
Image 01 Image 02